The Phase 1a study assessed the safety, tolerability and pharmacokinetics of ABI-H0731 in healthy volunteers. Favorable results from this segment of the study allow Assembly to advance ABI-H0731 into a Phase 1b study, which will assess its safety, pharmacokinetics and preliminary antiviral efficacy in patients with chronic HBV infection. The Phase 1b trial is expected to begin later this year. The company intends to report the results of the Phase 1a study at a scientific conference during 2017.
Separately, Assembly announced presentations at two upcoming conferences.
Topic: Dual Mechanism of Actions of Novel HBV Core Protein Allosteric Modifiers (CpAMs): Inhibiting Viral Replication and Blocking cccDNA Formation.
Topic: Second Wave of HBV Antivirals
The presentations will be available on the events page of the company's website at www.assemblybio.com
The information in this press release contains forward-looking statements regarding future events, including statements about the clinical and therapeutic potential of Assembly's development programs. Certain forward-looking statements may be identified by reference to a future period or periods or by use of forward-looking terminology such as "intends," "expected" or "developing." Assembly intends such forward-looking statements to be covered by the safe harbor provisions contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include: Assembly may experience delays in the completion of its clinical trials (whether caused by competition, adverse events, patient enrollment rates, shortage of clinical trial materials, regulatory issues or other factors); risks that data from its clinical trials may not be indicative of subsequent clinical trial results; risks related to the safety and efficacy of Assembly's product candidates; risks that early stage preclinical data may not be indicative of subsequent data when expanded to additional nonclinical models or to subsequent clinical data; risks that evolving competitive activity and intellectual property landscape may impair Assembly's ability to capture value for the technology. More information about the risks and uncertainties faced by Assembly are more fully detailed under the heading "Risk Factors" in Assembly's Annual Report on Form 10-K for the year ended
Assembly Biosciences, Inc.Investors: Lauren Glaser (415) 521-3828 Media: Barbara Lindheim (212) 584-2276 firstname.lastname@example.org
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