Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 154 913.42 93.93 19,302,686
Mutual Fund 179 213.89 23.48 4,825,358
Insider 5 76.84 6.61 1,359,257

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 81 109.29 10.91 2,241,427
Sellers 71 -89.65 8.98 -1,844,825
Net -- 19.64 1.93 396,602

Concentration

Value ($MM) % O/S Shares
Total Inst. 913.42 93.93 19,302,686
Top 10 Inst. 584.48 60.91 12,517,842
Top 20 Inst. 739.38 76.43 15,706,907
Top 50 Inst. 862.43 88.78 18,244,081

Style

Holders Value ($MM) % Inst Shares Shares
Growth 37 185.09 18.34 3,768,768
Aggressive Growth 1 0.34 0.03 7,000
Core Growth 30 52.38 5.19 1,067,531
Growth 6 132.36 13.11 2,694,237
Income 2 2.19 0.22 44,999
Income Value 1 2.05 0.20 41,626
Yield 1 0.14 0.02 3,373
Index 23 137.62 13.63 2,801,962
Other 55 438.38 45.18 9,284,371
Broker Dealer 12 11.23 1.11 228,458
GARP 10 29.89 3.02 621,015
Hedge Fund 29 294.42 30.86 6,342,556
Sector Specific 2 48.97 4.85 996,466
Specialty 1 0.11 0.01 1,942
VC/Private Equi 1 53.76 5.32 1,093,934
Value 15 15.38 1.57 322,154
Core Value 11 12.15 1.24 255,100
Deep Value 4 3.23 0.33 67,054

Location: Global Region

Holders % O/S Shares Share Change
North America 122 73.94 15,195,439 355,753
Europe 23 5.88 1,207,605 695,767
South/Central America 1 0.08 17,096 3,900
Asia 1 0.01 1,938 --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
EcoR1 Capital, LLC 2,943,164 14.32 -1 4/5/18
Jennison Associates LLC 2,435,246 11.85 314,946 3/31/18
Zlotnick Adam 1,161,009 5.65 -160,000 4/5/18
Acuta Capital Partners, LLC 1,115,000 5.43 27,896 3/31/18
venBio Select Advisor LLC 1,093,934 5.32 25,400 3/31/18
BlackRock Institutional Trust Company, N.A. 945,233 4.60 2,309 3/31/18
The Vanguard Group, Inc. 792,256 3.86 32,417 3/31/18
OrbiMed Advisors, LLC 721,166 3.51 -476,860 3/31/18
Lopatin Uri A 676,443 3.29 42,292 4/5/18
Small Derek A 634,391 3.09 -32,500 4/5/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Prudential Jennison Health Sciences Fund 1,579,048 7.68 -- 4/30/18
Vanguard Total Stock Market Index Fund 429,622 2.09 7,079 5/31/18
iShares Russell 2000 ETF 339,615 1.65 15,871 5/31/18
Janus Henderson Global Life Sciences Fund (US) 254,828 1.24 254,828 3/31/18
Vanguard Extended Market Index Fund 226,550 1.10 4,340 5/31/18
iShares Russell 2000 Growth ETF 143,681 0.70 8,540 5/31/18
PowerShares Dynamic Biotechnology & Genome Portfolio 120,760 0.59 -1,245 4/30/18
AXA Framlington Biotech Fund R GBP 116,936 0.57 -- 2/28/18
CREF Stock Account 82,886 0.40 20,598 3/31/18
Fidelity Extended Market Index Fund 77,499 0.38 3,910 4/30/18

* Insider values reflect direct beneficial ownership.

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