Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 175 938.75 97.69 24,874,641
Mutual Fund 202 272.32 30.02 7,644,329
Insider 5 54.31 5.38 1,371,117

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 118 243.89 25.75 6,556,398
Sellers 66 -75.56 7.85 -1,999,960
Net -- 168.32 17.90 4,556,438

Concentration

Value ($MM) % O/S Shares
Total Inst. 938.75 97.69 24,874,641
Top 10 Inst. 574.86 60.01 15,279,962
Top 20 Inst. 760.88 78.99 20,112,611
Top 50 Inst. 890.49 92.62 23,585,147

Style

Holders Value ($MM) % Inst Shares Shares
Growth 34 198.17 20.92 5,327,397
Core Growth 26 75.03 7.91 2,013,563
Growth 8 123.14 13.01 3,313,834
Income 4 11.06 1.17 298,774
Income Value 2 9.32 0.99 250,928
Yield 2 1.74 0.19 47,846
Index 26 143.30 15.15 3,856,751
Other 59 352.06 37.23 9,480,474
Broker Dealer 12 5.74 0.61 154,499
GARP 12 29.98 3.17 806,914
Hedge Fund 32 231.24 24.43 6,221,607
Sector Specific 1 45.81 4.84 1,233,371
Specialty 1 0.36 0.06 15,656
VC/Private Equi 1 38.94 4.12 1,048,427
Value 23 93.32 9.86 2,510,299
Core Value 16 88.37 9.34 2,378,843
Deep Value 7 4.95 0.52 131,456

Location: Global Region

Holders % O/S Shares Share Change
North America 135 78.70 20,040,227 5,101,979
Europe 26 7.14 1,818,232 545,509
Africa 1 0.39 100,431 100,431
South/Central America 3 0.06 15,428 15,428
Asia 2 0.03 8,855 6,916

Top Holders

Holder Shares Held % O/S Share Change Filing Date
EcoR1 Capital, LLC 2,943,164 11.56 -- 9/30/18
Jennison Associates LLC 2,477,182 9.73 5,567 9/30/18
Wellington Management Company, LLP 2,048,927 8.05 2,041,627 9/30/18
BlackRock Institutional Trust Company, N.A. 1,494,223 5.87 420,168 9/30/18
OrbiMed Advisors, LLC 1,233,371 4.84 512,205 9/30/18
Zlotnick Adam 1,161,009 4.56 -160,000 4/5/18
The Vanguard Group, Inc. 1,051,454 4.13 238,952 9/30/18
venBio Select Advisor LLC 1,048,427 4.12 85,000 9/30/18
Acuta Capital Partners, LLC 930,000 3.65 -232,000 9/30/18
Janus Henderson Investors 892,205 3.50 86,780 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,579,048 6.20 -- 9/30/18
Vanguard Total Stock Market Index Fund 580,197 2.28 152,007 9/30/18
iShares Russell 2000 ETF 462,133 1.81 2,262 10/31/18
Janus Henderson Global Life Sciences Fund (US) 359,997 1.41 105,169 6/30/18
Vanguard Extended Market Index Fund 279,209 1.10 50,958 9/30/18
Janus Henderson Global Life Sciences Fund (Ire) 236,606 0.93 29,706 9/30/18
Victory RS Small Cap Growth Fund 226,720 0.89 226,720 8/31/18
Emerald Growth Fund 218,394 0.86 99,075 9/30/18
Hartford Healthcare Fund 205,466 0.81 205,466 9/30/18
iShares Russell 2000 Growth ETF 189,923 0.75 -11,773 10/31/18

* Insider values reflect direct beneficial ownership.

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