Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 147 827.89 92.42 18,881,404
Mutual Fund 165 223.66 20.49 4,185,750
Insider 5 76.98 6.65 1,359,257

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 100 170.06 18.34 3,746,846
Sellers 40 -19.45 2.10 -428,353
Net -- 150.61 16.24 3,318,493

Concentration

Value ($MM) % O/S Shares
Total Inst. 827.89 92.42 18,881,404
Top 10 Inst. 555.53 62.37 12,741,942
Top 20 Inst. 689.20 77.51 15,835,450
Top 50 Inst. 788.20 88.19 18,017,102

Style

Holders Value ($MM) % Inst Shares Shares
Growth 34 135.22 14.60 2,983,072
Aggressive Growth 1 0.40 0.03 7,000
Core Growth 27 22.32 2.40 489,868
Growth 6 112.50 12.17 2,486,204
Income 1 1.82 0.20 40,230
Income Value 1 1.82 0.20 40,230
Index 23 124.79 13.50 2,757,060
Other 49 433.35 46.83 9,566,560
Broker Dealer 12 7.53 0.81 166,431
GARP 11 16.98 1.80 366,971
Hedge Fund 22 299.37 32.38 6,614,356
Sector Specific 2 61.01 6.60 1,348,326
Specialty 1 0.11 0.01 1,942
VC/Private Equi 1 48.35 5.23 1,068,534
Value 15 14.63 1.58 322,454
Core Value 12 11.91 1.28 262,368
Deep Value 3 2.72 0.29 60,086

Location: Global Region

Holders % O/S Shares Share Change
North America 113 74.83 15,287,742 3,340,220
Europe 23 2.65 542,186 257,160
South/Central America 1 0.08 17,096 3,900
Asia 1 0.01 1,938 252

Top Holders

Holder Shares Held % O/S Share Change Filing Date
EcoR1 Capital, LLC 2,943,164 14.41 -- 12/31/17
Jennison Associates LLC 2,120,300 10.38 347,025 12/31/17
Zlotnick Adam 1,321,009 6.47 -- 3/31/17
OrbiMed Advisors, LLC 1,198,026 5.86 450,000 12/31/17
Acuta Capital Partners, LLC 1,087,104 5.32 87,104 12/31/17
venBio Select Advisor LLC 1,068,534 5.23 161,372 12/31/17
BlackRock Institutional Trust Company, N.A. 942,924 4.62 105,529 12/31/17
The Vanguard Group, Inc. 759,839 3.72 98,807 12/31/17
Small Derek A 666,891 3.26 32,500 3/29/18
Lopatin Uri A 634,151 3.10 7,500 3/29/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Prudential Jennison Health Sciences Fund 1,579,048 7.73 -- 2/28/18
Vanguard Total Stock Market Index Fund 410,843 2.01 -- 2/28/18
iShares Russell 2000 ETF 323,744 1.58 -2,100 3/31/18
Vanguard Extended Market Index Fund 222,210 1.09 15,040 3/31/18
iShares Russell 2000 Growth ETF 135,141 0.66 206 3/31/18
PowerShares Dynamic Biotechnology & Genome Portfolio 122,277 0.60 -31,332 2/28/18
AXA Framlington Biotech Fund R GBP 116,936 0.57 -- 12/31/17
Fidelity Extended Market Index Fund 73,589 0.36 -- 2/28/18
Zacks Small-Cap Core Fund 71,962 0.35 71,962 11/30/17
Emerald Growth Fund 65,248 0.32 -24,774 1/31/18

* Insider values reflect direct beneficial ownership.

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