Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 151 430.06 89.09 22,807,646
Mutual Fund 324 147.75 33.90 8,653,874
Insider 10 39.19 7.80 1,994,994

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 73 72.47 15.10 3,865,726
Sellers 90 -70.80 13.94 -3,569,353
Net 1.67 1.16 296,373

Concentration

Value ($MM) % O/S Shares
Total Inst. 470.17 97.08 24,849,640
Top 10 Inst. 253.54 53.81 13,774,836
Top 20 Inst. 357.07 74.74 19,132,739
Top 50 Inst. 441.39 91.41 23,398,824

Style

Holders Value ($MM) % Inst Shares Shares
Growth 34 119.65 25.84 6,616,377
Aggressive Growth 1 0.33 0.07 16,955
Core Growth 25 51.68 10.17 2,602,345
Growth 8 67.64 15.61 3,997,077
Income 4 5.08 1.01 258,819
Income Value 2 5.03 1.00 255,707
Yield 2 0.04 0.01 3,112
Index 20 80.08 15.92 4,076,783
Other 54 160.08 33.33 8,531,982
Broker Dealer 13 5.29 1.05 268,767
GARP 13 29.56 5.90 1,509,626
Hedge Fund 25 87.22 18.84 4,823,473
Specialty -- -- -- --
VC Private Equity 2 18.39 3.65 933,993
Sector Specific 1 19.61 3.89 996,123
Value 19 57.32 11.31 2,895,171
Core Value 14 55.13 10.94 2,799,556
Deep Value 5 2.19 0.37 95,615

Location: Global Region

Holders % O/S Shares Share Value
North America 128 88.61 22,681,569 427,506,635
Europe 28 7.51 1,921,920 37,751,455
Asia / Pacific 5 0.90 230,236 4,599,321
Latin America 2 0.06 15,915 313,366

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Jennison Associates LLC 2,933,229 11.46 460,150 4/30/19
Wellington Management Company, LLP 2,278,614 8.90 -37,843 3/31/19
Armistice Capital LLC 1,590,000 6.21 462,000 4/15/19
BlackRock Institutional Trust Company, N.A. 1,341,596 5.24 -163,374 3/31/19
The Vanguard Group, Inc. 1,080,501 4.22 241,917 3/31/19
OrbiMed Advisors, LLC 996,123 3.89 -- 3/31/19
Janus Henderson Investors 952,885 3.72 -1,416 3/31/19
Avoro Capital Advisors 900,000 3.52 -100,000 3/31/19
Emerald Advisers LLC 886,522 3.46 128,269 3/31/19
State Street Global Advisors (US) 815,366 3.18 380,460 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,875,681 7.33 296,633 4/30/19
Vanguard Total Stock Market Index Fund 749,399 2.93 -- 5/31/19
Janus Henderson Global Life Sciences Fund (US) 423,535 1.65 12,611 3/31/19
iShares Russell 2000 ETF 412,837 1.61 -9,828 5/31/19
SPDR S&P Biotech ETF 402,176 1.57 402,176 3/31/19
Vanguard Extended Market Index Fund 288,841 1.13 -2,160 5/31/19
AXA Framlington Biotech Fund R GBP 256,076 1.00 -- 4/30/19
Emerald Growth Fund 251,404 0.98 -- 4/30/19
Janus Henderson Global Life Sciences Fund (Ire) 246,779 0.96 10,173 12/31/18
Biotech Growth Trust PLC 236,123 0.92 -- 1/31/19

* Insider values reflect direct beneficial ownership.

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