Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 179 941.99 98.62 25,112,923
Mutual Fund 212 226.33 32.22 8,203,598
Insider 5 54.31 5.38 1,371,117

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 114 242.67 25.66 6,534,343
Sellers 47 -60.32 6.33 -1,611,364
Net -- 182.35 19.33 4,922,979

Concentration

Value ($MM) % O/S Shares
Total Inst. 941.99 98.62 25,112,923
Top 10 Inst. 574.86 60.01 15,279,962
Top 20 Inst. 760.88 78.99 20,112,611
Top 50 Inst. 889.70 92.96 23,670,591

Style

Holders Value ($MM) % Inst Shares Shares
Growth 35 200.16 21.14 5,383,297
Core Growth 26 74.97 7.91 2,014,463
Growth 9 125.18 13.23 3,368,834
Income 4 11.06 1.17 298,865
Income Value 2 9.32 0.99 250,928
Yield 2 1.74 0.19 47,937
Index 27 143.31 15.17 3,862,902
Other 60 352.07 37.33 9,506,455
Broker Dealer 12 5.74 0.61 154,499
GARP 13 29.46 3.18 808,617
Hedge Fund 32 231.26 24.44 6,223,068
Sector Specific 1 45.81 4.84 1,233,371
Specialty 1 0.87 0.15 38,473
VC/Private Equi 1 38.94 4.12 1,048,427
Value 23 92.90 9.87 2,512,324
Core Value 16 87.94 9.35 2,380,868
Deep Value 7 4.96 0.52 131,456

Location: Global Region

Holders % O/S Shares Share Change
North America 136 79.02 20,122,077 5,131,330
Europe 27 7.14 1,819,070 501,960
Africa 1 0.39 100,431 100,431
South/Central America 3 0.06 15,428 15,128
Asia 2 0.03 8,824 6,908

Top Holders

Holder Shares Held % O/S Share Change Filing Date
EcoR1 Capital, LLC 2,943,164 11.56 -- 9/30/18
Jennison Associates LLC 2,477,182 9.73 5,567 9/30/18
Wellington Management Company, LLP 2,048,927 8.05 2,041,627 9/30/18
BlackRock Institutional Trust Company, N.A. 1,494,223 5.87 420,168 9/30/18
OrbiMed Advisors, LLC 1,233,371 4.84 512,205 9/30/18
Zlotnick Adam 1,161,009 4.56 -160,000 4/5/18
The Vanguard Group, Inc. 1,051,454 4.13 238,952 9/30/18
venBio Select Advisor LLC 1,048,427 4.12 85,000 9/30/18
Acuta Capital Partners, LLC 930,000 3.65 -232,000 9/30/18
Janus Henderson Investors 892,205 3.50 86,780 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,579,048 6.20 -- 11/30/18
Vanguard Total Stock Market Index Fund 580,197 2.28 -- 11/30/18
iShares Russell 2000 ETF 463,069 1.82 3,198 12/31/18
Janus Henderson Global Life Sciences Fund (US) 403,882 1.59 43,885 9/30/18
Fidelity Select Biotechnology Portfolio 287,800 1.13 100,100 11/30/18
Vanguard Extended Market Index Fund 280,807 1.10 1,598 11/30/18
Victory RS Small Cap Growth Fund 255,510 1.00 20,330 11/30/18
Janus Henderson Global Life Sciences Fund (Ire) 236,606 0.93 29,706 9/30/18
Biotech Growth Trust PLC 236,123 0.93 236,123 9/30/18
Emerald Growth Fund 218,394 0.86 -- 11/30/18

* Insider values reflect direct beneficial ownership.

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