Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 168 620.79 97.27 24,844,615
Mutual Fund 193 190.28 32.49 8,298,126
Insider 5 54.31 5.37 1,371,117

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 77 57.85 9.78 2,497,500
Sellers 92 -87.00 13.24 -3,380,499
Net -- -29.15 3.46 -882,999

Concentration

Value ($MM) % O/S Shares
Total Inst. 620.79 97.27 24,844,615
Top 10 Inst. 350.19 56.42 14,410,740
Top 20 Inst. 492.21 76.96 19,656,620
Top 50 Inst. 589.23 92.06 23,512,254

Style

Holders Value ($MM) % Inst Shares Shares
Growth 34 129.51 22.04 5,630,112
Aggressive Growth 1 0.95 0.16 41,814
Core Growth 25 51.81 8.63 2,202,962
Growth 8 76.76 13.25 3,385,336
Income 3 5.83 1.01 257,954
Income Value 2 5.77 1.00 254,957
Yield 1 0.06 0.01 2,997
Index 22 81.03 14.03 3,583,087
Other 57 204.23 35.29 9,012,906
Broker Dealer 12 2.65 0.46 117,278
GARP 11 20.24 3.50 894,919
Hedge Fund 30 134.79 23.26 5,941,166
Sector Specific 1 22.53 3.90 996,123
Specialty 1 0.63 0.12 29,427
VC/Private Equi 2 23.39 4.05 1,033,993
Value 18 62.48 10.76 2,747,098
Core Value 13 60.05 10.38 2,651,880
Deep Value 5 2.42 0.37 95,218

Location: Global Region

Holders % O/S Shares Share Change
North America 125 77.84 19,879,889 809,205
Europe 26 7.25 1,852,395 125,719
Asia 3 0.19 49,650 39,158
South/Central America 3 0.06 14,768 -660

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Jennison Associates LLC 2,476,190 9.70 -992 12/31/18
EcoR1 Capital, LLC 2,404,853 9.42 -538,311 12/31/18
Wellington Management Company, LLP 2,316,457 9.07 267,530 12/31/18
BlackRock Institutional Trust Company, N.A. 1,504,970 5.89 10,747 12/31/18
Zlotnick Adam 1,161,009 4.55 -160,000 4/5/18
venBio Select Advisor LLC 1,000,000 3.92 -48,427 12/31/18
OrbiMed Advisors, LLC 996,123 3.90 -237,248 12/31/18
Janus Henderson Investors 954,301 3.74 62,096 12/31/18
The Vanguard Group, Inc. 838,584 3.28 -212,870 12/31/18
Emerald Advisers LLC 758,253 2.97 -6,990 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,579,048 6.18 -- 1/31/19
iShares Russell 2000 ETF 433,585 1.70 -29,484 2/28/19
Vanguard Total Stock Market Index Fund 417,712 1.64 78,779 2/28/19
Janus Henderson Global Life Sciences Fund (US) 410,924 1.61 7,042 12/31/18
Fidelity Select Biotechnology Portfolio 294,833 1.15 -- 1/31/19
Vanguard Extended Market Index Fund 290,389 1.14 6,738 2/28/19
Victory RS Small Cap Growth Fund 253,889 0.99 5,020 1/31/19
Janus Henderson Global Life Sciences Fund (Ire) 246,779 0.97 10,173 12/31/18
Emerald Growth Fund 238,394 0.93 20,000 1/31/19
Biotech Growth Trust PLC 236,123 0.92 -- 11/30/18

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation