Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 154 216.61 82.42 21,446,532
Mutual Fund 355 128.53 33.44 8,592,321
Insider 12 40.72 8.20 2,109,494

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 66 29.19 10.87 2,830,784
Sellers 98 -50.58 17.38 -4,527,405
Net -21.39 6.51 -1,696,621

Concentration

Value ($MM) % O/S Shares
Total Inst. 257.34 90.62 23,556,026
Top 10 Inst. 138.09 53.98 14,047,915
Top 20 Inst. 192.78 69.19 17,990,340
Top 50 Inst. 235.59 83.61 21,736,462
Holders Value ($MM) % Inst Shares Shares
Growth 34 53.28 20.36 5,290,881
Aggressive Growth 2 0.31 0.12 31,090
Core Growth 28 21.46 7.90 2,054,538
Growth 4 31.51 12.35 3,205,253
Income 3 1.16 0.45 115,237
Income Value 1 0.59 0.23 60,106
Yield 2 0.57 0.21 55,131
Index 24 40.78 15.84 4,123,045
Other 55 87.20 33.40 8,698,554
Broker Dealer 15 3.63 1.42 369,165
GARP 12 13.76 5.14 1,337,326
Hedge Fund 28 69.82 26.85 6,992,063
Specialty -- --
VC Private Equity -- -- -- --
Sector Specific -- -- -- --
Value 20 26.08 9.75 2,538,577
Core Value 15 24.67 9.37 2,440,962
Deep Value 5 1.41 0.38 97,615

Location: Global Region

Holders % O/S Shares Share Change
North America 127 81.05 21,066,614 --
Europe 31 7.96 2,070,345 --
Asia / Pacific 6 1.15 298,778 --
Middle East 1 0.46 120,000 --
Latin America 1 -- 289 --
Holder Shares Held % O/S Share Change Filing Date
Armistice Capital LLC 2,468,000 9.48 468,000 9/30/19
Jennison Associates LLC 2,340,378 8.99 -215,259 9/30/19
Wellington Management Company, LLP 1,970,340 7.56 -280,900 9/30/19
BlackRock Institutional Trust Company, N.A. 1,525,922 5.86 92,011 9/30/19
Rock Springs Capital Management LP 1,300,000 4.99 740,000 9/30/19
The Vanguard Group, Inc. 1,163,828 4.47 -63,125 9/30/19
Janus Henderson Investors 906,748 3.48 -49,886 9/30/19
Emerald Advisers LLC 849,557 3.30 -31,007 9/30/19
Baker Bros. Advisors LP 803,246 3.08 -- 9/30/19
Sectoral Asset Management Inc. 719,896 2.76 -127,800 9/30/19
Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,626,364 6.24 -- 10/31/19
Vanguard Total Stock Market Index Fund 671,667 2.58 -- 10/31/19
iShares Russell 2000 ETF 496,439 1.91 -9,856 10/31/19
Janus Henderson Global Life Sciences Fund (US) 403,990 1.55 -6,888 9/30/19
Franklin Templeton Invest-Biotechnology Discovery 317,800 1.22 317,800 10/31/19
Vanguard Extended Market Index Fund 304,124 1.17 -14 10/31/19
AXA Framlington Biotech Fund R GBP 256,076 0.98 -- 10/31/19
Janus Henderson Global Life Sciences Fund (Ire) 228,805 0.88 -17,360 9/30/19
Wellington Global Healthcare Equity Fund 224,762 0.86 -- 9/30/19
iShares Russell 2000 Value ETF 191,492 0.74 -1,612 10/31/19