Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 122 533.35 102.18 17,776,947
Mutual Fund 139 145.55 21.54 3,747,928
Insider 2 2.01 0.26 44,465

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 56 37.85 5.82 1,011,708
Sellers 44 -37.56 6.13 -1,066,490
Net -- 0.29 0.31 -54,782

Concentration

Value ($MM) % O/S Shares
Total Inst. 533.35 102.18 17,776,947
Top 10 Inst. 371.58 74.65 12,987,483
Top 20 Inst. 463.95 91.32 15,887,856
Top 50 Inst. 517.64 99.67 17,340,231

Style

Holders Value ($MM) % Inst Shares Shares
Growth 20 75.13 12.05 2,096,773
Aggressive Growth 1 -- -- 200
Core Growth 15 6.64 1.09 188,833
Growth 4 68.49 10.97 1,907,740
Income 1 1.27 0.21 36,304
Income Value 1 1.27 0.21 36,304
Index 23 77.12 12.62 2,195,954
Momentum 1 0.02 0.01 911
Other 43 270.13 44.45 7,732,518
Broker Dealer 10 4.66 0.75 129,915
GARP 10 7.40 1.22 212,016
Hedge Fund 20 200.22 32.96 5,733,754
Sector Specific 1 26.12 4.30 748,026
Specialty 1 0.04 0.01 1,645
VC/Private Equi 1 31.68 5.21 907,162
Value 14 12.26 1.99 345,547
Core Value 10 9.94 1.61 279,810
Deep Value 4 2.31 0.38 65,737

Location: Global Region

Holders % O/S Shares Share Change
North America 98 71.04 12,358,965 -56,922
Europe 13 1.53 265,979 50,360
South/Central America 1 0.08 14,596 12,395
Asia 1 0.01 1,686 1,686

Top Holders

Holder Shares Held % O/S Share Change Filing Date
EcoR1 Capital, LLC 2,943,164 16.92 -- 9/30/17
Ecor1 Capital Fund Qualified L P 2,162,029 12.43 2,162,029 6/20/16
Jennison Associates LLC 1,773,275 10.19 -180,121 9/30/17
Zlotnick Adam 1,321,009 7.59 -- 3/31/17
Acuta Capital Partners, LLC 1,000,000 5.75 -30,072 9/30/17
venBio Select Advisor LLC 907,162 5.21 300,000 9/30/17
BlackRock Institutional Trust Company, N.A. 837,395 4.81 23,699 9/30/17
OrbiMed Advisors, LLC 748,026 4.30 -140,400 9/30/17
The Vanguard Group, Inc. 661,032 3.80 50,116 9/30/17
Small Derek A 634,391 3.65 -- 3/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Prudential Jennison Health Sciences Fund 1,342,370 7.72 -- 10/31/17
Vanguard Total Stock Market Index Fund 410,843 2.36 53,967 12/31/17
iShares Russell 2000 ETF 325,844 1.87 44,241 12/31/17
Vanguard Extended Market Index Fund 207,170 1.19 15,790 12/31/17
PowerShares Dynamic Biotechnology & Genome Portfolio 156,681 0.90 156,681 11/30/17
iShares Russell 2000 Growth ETF 134,935 0.78 20,052 12/31/17
AXA Framlington Biotech Fund R GBP 116,936 0.67 -1,419 9/30/17
Emerald Growth Fund 90,022 0.52 90,022 11/30/17
Fidelity Extended Market Index Fund 73,589 0.42 8,111 11/30/17
VY JPMorgan Small Cap Core Equity Portfolio 70,800 0.41 34,300 9/30/17

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation