Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 160 295.85 86.43 22,221,723
Mutual Fund 347 103.91 34.16 8,771,189
Insider 11 40.53 8.16 2,097,494

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 91 65.37 19.38 4,984,058
Sellers 81 -95.08 25.84 -6,644,580
Net -29.71 6.46 -1,660,522

Concentration

Value ($MM) % O/S Shares
Total Inst. 336.37 94.58 24,319,217
Top 10 Inst. 187.55 55.44 14,255,881
Top 20 Inst. 253.84 71.67 18,426,982
Top 50 Inst. 312.52 87.90 22,600,804
Holders Value ($MM) % Inst Shares Shares
Growth 32 77.08 22.03 5,663,255
Aggressive Growth 1 0.22 0.06 15,971
Core Growth 26 30.13 8.49 2,183,266
Growth 5 46.73 13.47 3,464,018
Income 3 1.63 0.47 121,520
Income Value 1 0.88 0.25 65,031
Yield 2 0.75 0.22 56,489
Index 25 54.60 15.84 4,072,522
Other 61 114.48 34.27 8,811,653
Broker Dealer 16 4.96 1.43 367,738
GARP 13 20.27 5.85 1,505,219
Hedge Fund 30 81.73 24.82 6,381,103
Specialty -- --
VC Private Equity 1 0.46 0.13 33,993
Sector Specific 1 7.06 2.04 523,600
Value 20 39.34 11.17 2,872,585
Core Value 15 37.57 10.77 2,770,224
Deep Value 5 1.77 0.40 102,361

Location: Global Region

Holders % O/S Shares Share Change
North America 135 85.99 22,110,089 --
Europe 28 7.64 1,964,570 --
Asia / Pacific 7 0.95 244,269 --
Latin America 1 -- 289 --
Holder Shares Held % O/S Share Change Filing Date
Jennison Associates LLC 2,555,637 9.94 -377,592 6/30/19
Wellington Management Company, LLP 2,251,240 8.76 -27,374 6/30/19
Armistice Capital LLC 2,000,000 7.78 410,000 6/30/19
BlackRock Institutional Trust Company, N.A. 1,433,911 5.58 92,315 6/30/19
Rock Springs Capital Management LP 1,300,000 5.06 740,000 9/25/19
The Vanguard Group, Inc. 1,226,953 4.77 146,452 6/30/19
Janus Henderson Investors 956,634 3.72 3,749 6/30/19
Emerald Advisers LLC 880,564 3.42 -5,958 6/30/19
Sectoral Asset Management Inc. 847,696 3.30 131,898 6/30/19
Baker Bros. Advisors LP 803,246 3.12 654,659 6/30/19
Fund Shares Held % O/S Share Change Filing Date
PGIM Jennison Health Sciences Fund 1,626,364 6.33 -- 8/31/19
Vanguard Total Stock Market Index Fund 671,667 2.61 -99,900 9/30/19
iShares Russell 2000 ETF 506,295 1.97 42,064 9/30/19
Janus Henderson Global Life Sciences Fund (US) 410,878 1.60 -12,657 6/30/19
Vanguard Extended Market Index Fund 304,138 1.18 3,909 9/30/19
AXA Framlington Biotech Fund R GBP 256,076 1.00 -- 8/31/19
Emerald Growth Fund 251,404 0.98 -- 8/31/19
Janus Henderson Global Life Sciences Fund (Ire) 246,165 0.96 14,661 6/30/19
Wellington Global Healthcare Equity Fund 237,002 0.92 -2,040 7/31/19
iShares Russell 2000 Value ETF 193,104 0.75 7,440 9/30/19