75000 - Document - Document And Entity Information
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75010 - Statement - CONSOLIDATED BALANCE SHEETS
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75020 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)
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75030 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
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75040 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY
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75050 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
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75060 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995457 - Disclosure - Nature of Business
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995467 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements
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995477 - Disclosure - Related Party
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995487 - Disclosure - Investments in Marketable Securities
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995497 - Disclosure - Property and Equipment, Net
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995507 - Disclosure - Other Accrued Expenses
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995517 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets Impairment
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995527 - Disclosure - Restructurings
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995537 - Disclosure - Stockholders' Equity
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995547 - Disclosure - Stock-Based Compensation
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995557 - Disclosure - Collaboration Agreements
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995567 - Disclosure - HBV Research Agreement with Indiana University
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995577 - Disclosure - Income Taxes
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995587 - Disclosure - Operating Leases
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995597 - Disclosure - Employee Benefit Plan
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995607 - Disclosure - Segment Reporting
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995617 - Disclosure - Subsequent Event
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995627 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)
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995637 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Tables)
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995647 - Disclosure - Investments in Marketable Securities (Tables)
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995657 - Disclosure - Property and Equipment, Net (Tables)
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995667 - Disclosure - Other Accrued Expenses (Tables)
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995677 - Disclosure - Restructurings (Tables)
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995687 - Disclosure - Stockholders' Equity (Tables)
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995697 - Disclosure - Stock-Based Compensation (Tables)
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995707 - Disclosure - Collaboration Agreements (Tables)
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995717 - Disclosure - Income Taxes (Tables)
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995727 - Disclosure - Operating Leases (Tables)
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995737 - Disclosure - Segment Reporting (Tables)
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995747 - Disclosure - Nature of Business - Additional Information (Details)
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995757 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Additional Information (Details)
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995767 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Earnings Per Share, Basic and Diluted (Details)
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995777 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details)
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995787 - Disclosure - Related Party - Additional Information (Details)
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995797 - Disclosure - Investments in Marketable Securities - Schedule of Investments in Marketable Available-for-Sale Securities (Details)
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995807 - Disclosure - Investments in Marketable Securities - Additional Information (Details)
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995817 - Disclosure - Investments in Marketable Securities - Schedule of Fair Value of Financial Assets (Details)
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995827 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details)
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995837 - Disclosure - Property and Equipment, Net - Additional Information (Details)
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995847 - Disclosure - Other Accrued Expenses - Schedule of Other Accrued Expenses (Details)
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995857 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets Impairment - Additional Information (Details)
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995867 - Disclosure - Restructurings - Additional Information (Details)
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995877 - Disclosure - Restructurings - Schedule of Accrued Restructuring Charges (Details)
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995887 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995897 - Disclosure - Stockholders' Equity - Summary of Warrants and Pre-funded Warrants to Purchase Shares of Common Stock Issued and Outstanding (Details)
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995907 - Disclosure - Stockholders' Equity - Summary of Warrants and Pre-funded Warrants to Purchase Shares of Common Stock Issued and Outstanding (Parenthetical) (Details)
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995917 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995927 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity and Related Information (Details)
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995937 - Disclosure - Stock-Based Compensation - Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants (Details)
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995947 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units and Related Information (Details)
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995957 - Disclosure - Stock-Based Compensation - Summary of Performance Stock Units and Related Information (Details)
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995967 - Disclosure - Stock-Based Compensation - Schedule of Recognized Stock-Based Compensation Expense (Details)
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995977 - Disclosure - Collaboration Agreements - Schedule of Changes in Contract Liabilities (Details)
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995987 - Disclosure - Collaboration Agreements - Schedule of Collaboration Revenue Recognized with the Period (Details)
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995997 - Disclosure - Collaboration Agreements - Additional Information (Details)
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996007 - Disclosure - HBV Research Agreement with Indiana University - Additional Information (Details)
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996017 - Disclosure - Income Taxes - Schedule of Income Tax Expense (Details)
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996027 - Disclosure - Income Taxes - Effective Income Tax Rate Reconciliation (Details)
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996037 - Disclosure - Income Taxes - Additional Information (Details)
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996047 - Disclosure - Income Taxes - Components of Deferred Taxes (Details)
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996057 - Disclosure - Income Taxes - Summary of Net Operating Loss and Tax Credit Carryforwards (Details)
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996067 - Disclosure - Income Taxes - Activity Related to Gross Unrecognized Tax Benefits (Details)
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996077 - Disclosure - Operating Leases - Additional Information (Details)
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996087 - Disclosure - Operating Leases - Schedule of Quantitative Information of Operating Leases (Details)
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996097 - Disclosure - Operating Leases - Schedule of Maturities Operating Lease Liabilities (Details)
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996107 - Disclosure - Operating Leases - Schedule of Maturities Operating Lease Liabilities (Details) 2
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996117 - Disclosure - Employee Benefit Plan - Additional Information (Details)
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996127 - Disclosure - Segment Reporting - Additional Information (Details)
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996137 - Disclosure - Segment Reporting - Schedule of Segment Expenses and Other Segment Items (Details)
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Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Deferred tax liabilities, operating lease right-of-use assets.
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Operating lease right-of-use assets
Concentration Risk Type [Axis]
Schedule of Nonvested Performance-Based Units Activity [Table Text Block]
Summary of Performence Stock Units and Related Information
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued
Preferred stock, shares issued
Statement of Financial Position Location, Balance [Domain]
Balance Sheet Location
Research And Discovery [Member]
Research and discovery.
Research And Discovery
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Schedule of Fair Value of Financial Assets
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Tax credits:
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental non-cash investing and financing activities
Plan Name [Axis]
Plan Name
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Proceeds from Warrant Exercises
Proceeds from the exercise of warrants
Operating Expenses [Abstract]
Operating expenses
Fair Value, Inputs, Level 2 [Member]
Level 2
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax asset, net of valuation allowance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted Average Exercise Price Per Share
Common Stock, Shares Authorized
Common stock, shares authorized
Option Indexed to Issuer's Equity, Type [Axis]
Option Indexed to Issuer's Equity, Type
Product and Service [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Shell Company
Entity Shell Company
Potential Milestone Payments.
Potential Milestone Payments
Potential milestone payments
Other Accrued Liabilities, Current
Other accrued expenses
Cash and Cash Equivalent
Cash and cash equivalents
Amortized Cost
Class A Warrants
Class A Warrants
Subsidiary, Sale of Stock [Line Items]
Subsidiary Sale Of Stock [Line Items]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued
Common stock, shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Cash equivalents at carrying value and available for sale debt securities gross unrealized gain.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Gain
Gross Unrealized Gain
Revenue from Contract with Customer Benchmark
Revenue from Contract with Customer Benchmark [Member]
Asset Class [Domain]
Statement [Table]
Statement [Table]
Contract with Customer, Liability,Premium on Purchase of the Company's Common Stock
Contract with customer, liability,premium on purchase of the company's common stock.
Premium on purchase of the Company's common stock
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increases related to current year tax positions
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease liabilities arising from obtaining ROU assets
ROU assets exchanged for new operating lease liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant-date fair value of options granted
Fair value of common stock purchased
Fair Value Of Common Stock Purchased
Fair value of common stock purchased.
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Purchase price after discount (in percent)
Statement [Line Items]
Statement [Line Items]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Options , Expired
Other revenue
Service, Other [Member]
Warrant [Member]
Warrants to purchase common stock
Entity Filer Category
Entity Filer Category
Liabilities and Equity
Total liabilities and stockholders' equity
Payables and Accruals [Abstract]
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent
Changes in unrecognized tax benefits
A B I Five Three Six Six [Member]
ABI-5366.
ABI-5366
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options vested and exercisable
Restructuring Type [Axis]
Restructuring Type
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Employee severance and related benefits
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase (decrease) in valuation allowance
Operating Loss Carryforwards [Table]
Prepaid Expenses and Other Current Assets [Member]
Prepaid Expenses and Other Current Assets
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Restructuring and Related Costs [Table Text Block]
Summary of Restructuring Costs
Cash and Cash Equivalents, Fair Value Disclosure
Fair Value
Cash equivalents
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Tax computed at federal statutory rate
Purchase price per share
Shares Issued, Price Per Share
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Contract with Customer, Liability,Cash Received
Contract with customer, liability,cash received.
Cash received
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate
Options to purchase common stock
Income Tax Jurisdiction [Axis]
Income Tax Authority
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
Net operating losses
Long-term marketable securities
Fair Value, Long-term marketable securities
Debt Securities, Available-for-Sale, Noncurrent
Asset-Backed Securities [Member]
Asset-backed securities
Debt Securities, Available-for-Sale, Term
Available for sale securities maturity term
Additional Paid in Capital, Common Stock
Additional paid-in capital
Effective income tax rate reconciliation uncertain tax positions rate.
Effective Income Tax Rate Reconciliation Uncertain Tax Positions Rate
Uncertain tax positions
Related Party
Related Party [Member]
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies and Recent Accounting Pronouncements
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment
Effective income tax rate reconciliation return to provision adjustments.
Effective Income Tax Rate Reconciliation Return To Provision Adjustments
Return to provision adjustments
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Options, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Option, Granted
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Earnings Per Share, Basic and Diluted
Proceeds from The Issuance of Common Stock and Warrants in A Registered Direct Offering, Net of Issuance Costs
Proceeds from the issuance of common stock and warrants in a registered direct offering, net of issuance costs.
Proceeds from the issuance of common stock and warrants in a registered direct offering, net of issuance costs
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Non-taxable or nondeductible items:
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share - basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Option, Outstanding at end of period
Options, Outstanding at beginning of period
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Schedule of Investments in Marketable Available-for-Sale Securities
Regulatory and Commercial Milestones
Regulatory And Commercial Milestones [Member]
Regulatory and commercial milestones.
Cash and cash equivalent gross unrealized loss.
Cash And Cash Equivalent Gross Unrealized Loss
Gross Unrealized Loss
Liabilities, Current
Total current liabilities
Schedule of accrued restructuring charges.
Schedule Of Accrued Restructuring Charges Table [Text Block]
Schedule of Accrued Restructuring Charges
Increase (Decrease) in Accounts Receivable
Accounts receivable from collaboration
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Collaboration Agreement
Collaboration Agreement [Abstract]
Proceeds From Issuance Of Common Stock And Warrants In Private Placements to Related Party, Net of Issuance Costs
Proceeds from issuance of common stock and warrants in private placements to related party, net of issuance costs.
Proceeds from the issuance of common stock and warrants in private placements to a related party, net of issuance costs
Domestic Tax Jurisdiction [Member]
Federal
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Tax credits:
Deferred tax assets operating lease liabilities.
Deferred Tax Assets Operating Lease Liabilities
Operating lease liabilities
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Percentage of workforce reduced
Equity, Attributable to Parent [Abstract]
Stockholders' equity
Microbiome Purchase Agreement
Microbiome purchase agreement.
Microbiome Purchase Agreement [Member]
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Nonmonetary Transaction Type [Axis]
Subsidiary or Equity Method Investee, Sale of Stock, Type [Table]
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Net operating losses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Option, Forfeited
Proceeds from Issuance Initial Public Offering
Net proceeds from the issuance of common stock through equity plans
Net proceeds
Sale of stock, price per share
Sale of Stock, Price Per Share
Common Stock and Warrant [Member]
Common stock and warrant.
Common Stock and Warrant
Total intrinsic value of options exercised
Percentage share of profits and operating loss for products
Percentage Share of Profits and Operating Loss for Products
Percentage share of profits and operating loss for products.
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Listing Qualifications of the Stock Market Description
Listing qualifications of the stock market description.
Listing qualifications of the Nasdaq stock market, description
Leases [Abstract]
Contract with Customer, Liability
Contract liability/deferred revenue
Deferred revenue balance at end of period
Deferred revenue balance at beginning of period
Contract with Customer, Liability, Total
Amounts included in deferred revenue from a related party at the beginning of the period
Amendment Flag
Amendment Flag
Proceeds From the Issuance of Common Stock, Pre Funded Warrants and Warrants in an Underwritten Offering, Net of Issuance Costs
Proceeds from the issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs.
Proceeds from the issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs
Product and Service [Domain]
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Tax computed at federal statutory rate
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Warrant expiration date
Warrant Exercisable Date
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants to purchase
Pre-funded warrants sold to purchase common stock
Collaboration revenue
Collaboration Revenue [Member]
Collaboration revenue.
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
August Eleven Two Zero Two Five Warrants Member [Member]
August Eleven Two Zero Two Five Warrants Member
August 11 2025 Warrants
Segment reporting, CODM, profit (loss) measure
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock [Member]
Common Stock
Impairment, Intangible Asset, Indefinite-Lived (Excluding Goodwill), Statement of Income or Comprehensive Income [Extensible Enumeration]
Cybersecurity Risk Role of Management [Text Block]
Defined Contribution Plan, Employer Discretionary Contribution Amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Option, Granted
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Debt Securities, Available-for-Sale [Line Items]
Investments in marketable securities:
A B I Four Three Three Four [Member]
ABI-4334.
ABI-4334
Reverse Stock Split Member
Reverse Stock Split [Member]
Reverse stock split member.
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Income Tax, Policy [Policy Text Block]
Income Taxes
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Goodwill and Intangible Assets Disclosure [Text Block]
Goodwill and Indefinite-Lived Intangible Asset Impairment
Statement of Financial Position Location, Balance [Axis]
Balance Sheet Location
Investment Type [Axis]
Investment Type
Operating Lease, Right-of-Use Asset
Operating lease right-of-use (ROU) assets
Operating lease, right-of-use asset
Unrealized loss position
Debt Securities, Available-for-Sale, Unrealized Loss Position
Deferred Tax Assets, Gross
Total deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Payments to Acquire Debt Securities, Available-for-Sale
Purchases of marketable securities
Expiration date of each operating loss carry forward
Operating Loss Carry Forwards Expiration Period
Expiration Years
Class of Warrant or Right [Axis]
Document Type
Document Type
Goodwill and Intangible Assets, Policy [Policy Text Block]
Goodwill and Indefinite-Lived Intangible Asset
Income Taxes Paid, Net
Total income taxes paid, net of refunds received
Income taxes paid, net of (refunds received)
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Short-Term Investments [Abstract]
Short-term marketable securities
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Investments, Debt and Equity Securities [Abstract]
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Facility and Other Expenses
Facility and other expenses.
Facility and other expenses
Percentage Share Of Costs And Profits
Percentage share of costs and profits.
Percentage share of costs and profits
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net increase in cash and cash equivalents
Subsequent Event Type [Domain]
Subsequent Event Type
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of loss per share
Impairment of long-lived assets
Impairment of Long-Lived Assets to be Disposed of
Common Stock, Par or Stated Value Per Share
Common stock, par value
Proceeds from Issuance of Warrants
Total proceeds from the issuance of warrants
2024 At the Market Offerings
Two Thousand And Twenty Four At The Market Offerings [Member]
Two Thousand And Twenty Four At The Market Offerings.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options Outstanding, Weighted Average Remaining Contractual Term (Years)
Realized gains and losses
Realized Investment Gains (Losses)
Realized Investment Gains (Losses), Total
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Options , Exercised
Issuance of common stock upon exercise of stock options (in shares)
Total intrinsic value of options exercised
Future Collaboration Related Payments Received
Future collaboration related payments received.
Future collaboration-related payments received
Opt in Payment Received Upon Exercise of Option
Opt in payment received upon exercise of option
OptInPaymentReceivedUponExerciseOfOption
Accrued Liabilities, Current
Accrued expenses
Total accrued expenses
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Compensation expense:
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Address, State or Province
Entity Address, State or Province
Schedule of Collaboration revenue recognized with the period
Schedule Of Collaboration Revenue Recognized With Period Table [Text Block]
Schedule of Collaboration Revenue Recognized with the Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Ending of period
Beginning of period
Outstanding awards
Non-Refundable Payment Received
Non-refundable payment received.
Non-refundable payment received
Increase (Decrease) in Other Accrued Liabilities
Other accrued expenses
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Cash equivalents at carrying value and available for sale debt securities estimated fair value.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Estimated Fair Value
Fair Value
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expense and Accruals
Common Stock, Capital Shares Reserved for Future Issuance
Common stock, capital shares reserved for future issuance
Percentage cover of research and development costs
Percentage Cover of Research and Development Costs
Percentage cover of research and development costs.
ABI-7272
ABISevenTwoSevenTwo [Member]
ABISevenTwoSevenTwo.
Class of Warrant or Right [Domain]
Contract with Customer, Liability, Revenue Recognized
Amounts included in deferred revenue at the beginning of the period
Revenue recognized
Number of fellow-contributed programs
Number of Fellow-contributed Programs
Number of fellow-contributed programs.
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State tax, net of federal income tax effect
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Recognized Stock-Based Compensation Expense
Short term marketable securities.
Short Term Marketable Securities [Member]
Short-term marketable securities
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock upon exercise of stock options
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Components of Deferred Taxes
Performance conditions not yet Met
PSUs
Unvested PSUs
Subsequent Event [Member]
Subsequent Event
Seventh Year of Collaboration Agreement
Seventh Year of Collaboration [Member]
Seventh year of collaboration.
Marketable Securities, Policy [Policy Text Block]
Investments in Marketable Securities
Restructuring one time termination cost.
Restructuring one-time termination Cost
Threshold payment of opt-in fee
Threshold Payment of Opt-in Fee
Threshold payment of opt-in fee.
Property, Plant and Equipment [Abstract]
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Other Assets, Noncurrent
Other assets
Marketable securities
Short-term marketable securities
Fair Value, Short-term marketable securities
Antidilutive Securities [Axis]
Antidilutive Securities
Operating Loss Carryforwards [Line Items]
Option, Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Option, Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Total fair value of awards vested and settled
Arbutus agreement.
Arbutus Agreement [Member]
Arbutus Biopharma Agreement
State and Local Jurisdiction [Member]
State
Represents the number of approved products.
Number Of Approved Products
FDA approved products (in products)
Related Party Transaction [Axis]
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss
Cumulative restructuring charges
Cumulative Restructuring Charges
Cumulative Restructuring Charges
Customer [Domain]
Registered Direct Offering [Member]
Registered direct offering.
Registered Direct Offering
Goodwill, Impairment Loss
Goodwill impairment charge
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Intrinsic Value, Amount Per Share [Abstract]
Weighted Average Fair Value Per RSU at Grant Price
Weighted Average Fair Value Per PSU at Grant Price
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding
Available for sale debt securities accumulated gross unrealized gain before tax current.
Available for Sale Debt Securities Accumulated Gross Unrealized Gain before Tax Current
Gross Unrealized Gain, Short-term marketable securities
Minimum [Member]
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted
Financial Instrument [Axis]
Financial Instrument
Assets, Current [Abstract]
Current assets
Deferred revenue
Deferred Tax Assets Deferred Revenue
Deferred tax assets deferred revenue.
Initial non-cancellable term
Initial Non Cancellable Term
Initial non-cancellable term.
Pre-funded Warrants [Member]
Pre-funded Warrants
pre-funded warrant
Fair Value, Inputs, Level 3 [Member]
Level 3
Share based compensation arrangement fair value assumptions exercise price.
Share Based Compensation Arrangement Fair Value Assumptions Exercise Price
Exercise price
Segment Reporting [Abstract]
Liabilities, Current [Abstract]
Current liabilities
Restructuring and Related Activities Disclosure [Text Block]
Restructurings
Increase (decrease) in accrued research and development expenses.
Increase Decrease In Accrued Research And Development Expenses
Accrued research and development expenses
Number of trading days volume considered for weighted average price to calculate premium
Number of Trading Days Volume Considered for Weighted Average Price to Calculate Premium
Number of trading days volume considered for weighted average price to calculate premium.
Related Party Transactions [Abstract]
Shares, Outstanding
Balance (in shares)
Balance (in shares)
Net operating loss carryforwards
Operating Loss Carryforwards
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable from collaboration
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts receivable from collaboration with a related party
Commitments and Contingencies
Commitments and contingencies
Lessee, Leases [Policy Text Block]
Leases
August 11 2025 One Warrants
August Eleven Two Zero Two Five Warrants One[Member]
August Eleven Two Zero Two Five Warrants One[Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Ending of period
Beginning of period
Two thousand and twenty at the market offerings.
Two Thousand And Twenty At The Market Offerings [Member]
2020 At the Market Offerings
2020 ATM
General and Administrative Expense
General and Administrative Expense [Member]
General and Administrative
Operating Lease, Liability
Operating lease, liability
Operating lease liabilities
Operating Lease, Liability, Total
Auditor Firm ID
Auditor Firm ID
Costs Associated with Exit or Disposal Activities or Restructurings, Policy [Policy Text Block]
Restructurings Charges
Premium on purchase of common stock
Sale Of Stock Consideration Premium On Purchase Of Common Stock
Sale of stock consideration premium on purchase of common stock.
Reverse stock split description
Stockholders' Equity, Reverse Stock Split
Concentration Risk Benchmark [Axis]
HPI Program License [Member]
HPI Program License
HPI Program License
Permanent items
Income Tax Reconciliation Nondeductible Expense Permanent Items
Income tax reconciliation, nondeductible expense, permanent items.
Vebicorvir [Member]
Vebicorvir.
Vebicorvir
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Changes in valuation allowance
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Purchase price per share of additional shares description
Purchase Price Per Share of Additional Shares Description
Purchase price per share of additional shares description.
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares and pre-funded warrants outstanding - basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Options vested and exercisable
Segment Reporting, Expense Information Used by CODM, Description
Segment reporting, expense information used by CODM
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Effective Income Tax Rate Reconciliation
Costs incurred
Restructuring Charges Except Non-cash Stock Based Compensation Expense
Restructuring charges except non-cash stock based compensation expense.
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Number of shares issued in connection with reverse stock split
Stock Issued During Period, Shares, Reverse Stock Splits
TwoThousandEighteenEmployeeStockPurchasePlanMember
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
2018 ESPP
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Deferred Tax Assets, Net [Abstract]
Deferred tax assets:
Subsequent Events [Text Block]
Subsequent Event
Related Party
Related Party Transactions Disclosure [Text Block]
Stock Options [Member]
Stock options
Stock options
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Payment Of Opt In Fee
Payment of opt-in fee.
Payment of opt-in fee
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Changes in valuation allowance
Equity, Attributable to Parent
Balance
Balance
Total stockholders' equity
Warrant Issued
Class Of Warrant Or Right Issued
Class of warrant or right issued.
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Statement of Stockholders' Equity [Abstract]
Consideration of assets sale agreement to be received.
Consideration Of Assets Sale Agreement To Be Received
Consideration from asset purchase agreement, entitled to receive
Type of Restructuring [Domain]
Type of Restructuring
Proceeds from issuance of common stock under employee stock purchase plan.
Proceeds From Issuance Of Common Stock Under Employee Stock Purchase Plan
Proceeds from the issuance of common stock under ESPP
Cash Equivalents [Member]
Cash equivalents
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Leasehold Improvements [Member]
Leasehold improvement
Entity Address, Address Line Two
Entity Address, Address Line Two
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Number of Shares
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Other Accrued Expenses
Related Party Transaction, Reimbursement from Related Party
Related party transaction, reimbursement from related party.
Reimburse agreed amount
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Activity Related to Gross Unrecognized Tax Benefits
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Segment reporting, CODM, individual title and position or group name
Plan Name [Domain]
Plan Name
Percentage of royalties on net sales
Percentage of Royalties on Net Sales
Percentage of royalties on net sales
Accrued restructuring charges current.
Accrued Restructuring Charges Current
Accrued balance
Accrued balance
Accrued restructuring charges
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Accrued research and development expenses
Options expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
State
Current State and Local Tax Expense (Benefit)
Current
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Class of Warrant or Right, Outstanding
Warrant Outstanding
Cash equivalents at carrying value and available for sale debt securities gross unrealized loss.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Loss
Gross Unrealized Loss
Class Of Warrant Or Rights Date From Which Warrants Or Rights Issuable
Class Of Warrant Or Rights Date From Which Warrants Or Rights Issuable
Warrant Issue Date
Related and Nonrelated Parties [Axis]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Accounting Standards Update [Extensible Enumeration]
Entity Address, City or Town
Entity Address, City or Town
Issuance of Common Stock and Warrants in Private Placements to A Related Party, Net of Issuance Costs
Issuance of common stock and warrants in private placements to a related party, net of issuance costs.
Issuance of common stock and warrants in private placements to a related party, net of issuance costs (in shares)
Security Exchange Name
Security Exchange Name
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other
Property, Plant and Equipment, Gross
Total property and equipment
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Current:
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Counterparty Name
Counterparty Name [Axis]
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Options expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Concentration Risk Type [Domain]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Increase decrease in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Warrant exercise price
Pre-funded warrants exercise price per share
Warrant Exercise Price per Share
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Document Period End Date
Document Period End Date
Number of patients
Number of Patients
Number of Patients
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Other Risks and Uncertainties
Other risks and uncertainties.
Other Risks And Uncertainties Policy [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Options vested and exercisable
Impairment of Intangible Assets, Indefinite-Lived (Excluding Goodwill)
Indefinite-lived intangible assets impairment charges
Statement of Financial Position [Abstract]
Unvested RSUs
Restricted Stock Units (RSUs) [Member]
RSUs
Revenue [Policy Text Block]
Revenue Recognition and Accounts Receivable from Collaborations
Effective Income Tax Rate Reconciliation Nondeductible Expense Covered Employee Compensation
Effective income tax rate reconciliation, nondeductible expense, covered employee compensation.
Covered employee compensation
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss
Deferred Tax Liabilities, Net
Net deferred tax liability
Deferred Tax Liabilities, Net, Total
Deferred tax liabilities
Compensation and Employee Benefit Plans [Text Block]
Employee Benefit Plan
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Warrants and Rights Outstanding, Maturity Date
Warrant Expiration Date
Liabilities
Total liabilities
Financial Instruments [Domain]
Financial Instruments
Restructuring costs reversal of stock-based compensation expense
Restructuring costs reversal
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Cash equivalents at fair value.
Cash Equivalents At Fair Value [Abstract]
Cash equivalents
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares and pre-funded warrants outstanding - diluted
Securities Act File Number
Entity File Number
Unrealized gain (loss) on marketable debt securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain (loss) on marketable securities
Cover [Abstract]
Issuance Of Common Stock Upon Exercise Of Warrants, Shares
Issuance of common stock upon exercise of warrants, shares.
Issuance of common stock upon exercise of warrants (in Shares)
Income Tax Reconciliation Nondeductible Expense Covered Employee Compensation
Income tax reconciliation, nondeductible expense, covered employee compensation.
Covered employee compensation
Segment Reporting Information, Profit (Loss) [Abstract]
Less:
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Forfeited
Investments [Domain]
Investments
US Treasury Securities [Member]
U.S. treasury securities
U.S. treasury securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Shares reserved for issuance (in shares)
Number of Operating Segments
Operating segments (in segments)
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Collaboration Revenue Recognized from Related Party in Period [Abstract]
Collaboration Revenue Recognized from Related Party in Period.
Collaboration revenue from a related party recognized in the period from:
Nonvested Restricted Stock Shares Activity [Table Text Block]
Summary of Restricted Stock Units and Related Information
Revenue recognized
Collaboration revenue
Collaboration revenue from a related party
Strategic License Agreements:
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Purchase Commitment, Remaining Minimum Amount Committed
Potential milestone payment
Deferred Tax Assets, Other
Other
Revenue recognized
Decrease in contract with customer liability revenue recognized
Decrease in contract with customer liability revenue recognized.
Restructuring charges incurred
Restructuring Charges
Costs incurred
Restructuring Charges, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Total Intrinsic Value
Fair value assets between levels transfers amount.
Fair Value Assets Between Levels Transfers Amount
Fair value assets transfers between level 1, level 2 or level 3
Recently Adopted Accounting Standards and Accounting Pronouncements to Be Adopted
New Accounting Pronouncements, Policy [Policy Text Block]
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Maturities Operating Lease Liabilities
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share
Deferred revenue - short-term
Contract with Customer, Liability, Current
Deferred revenue from a related party - short-term
Less: current portion
Gain (Loss) on Disposition of Assets
Gain on sale assets
Gain (Loss) on Disposition of Assets, Total
Variable consideration for reimbursable costs
Variable Consideration for Reimbursable Costs
Variable consideration for reimbursable costs.
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Amount
Depreciation
Depreciation
Depreciation, Total
Investment, Type [Extensible Enumeration]
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Operating Lease, Liability, Current
Operating lease liabilities - short-term
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Non-refundable payment received
NonRefundable Payment Received
Non refundable payment received.
Operating Expenses
Total operating expenses
Accrued Liabilities, Current [Abstract]
Accrued expenses:
Research and Development Expense
Research and development
Research and development expense
Total research and development
Lessee, Operating Leases [Text Block]
Operating Leases
Amortized Cost, Short-term marketable securities
Debt Securities, Available-for-Sale, Amortized Cost, Current
Amortized Cost, Short-term marketable securities
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Income Tax Expense
Statement of Cash Flows [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs
Contract with Customer, Liability,Accounts Receivable from Collaboration with a Related Party
Contract with customer, liability,accounts receivable from collaboration with a related party.
Accounts receivable from collaboration with a related party
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity and Related Information
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Share-based payment awards
Cash equivalents at carrying value and available for sale debt securities amortized cost.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Amortized Cost
Amortized Cost
Equity [Text Block]
Stockholders' Equity
Other
Deferred Tax Liabilities, Other
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Option, Outstanding at beginning of period
Options , Outstanding at end of period
Option, Outstanding at beginning of period
Issuance of Common Stock and Warrants in Private Placements to A Related Party Value, Net of Issuance Costs
Issuance of common stock and warrants in private placements to a related party value, net of issuance costs.
Issuance of common stock and warrants in private placements to a related party, net of issuance costs
Operating Lease, Cost
Operating lease cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Options expected to vest
Assets [Abstract]
ASSETS
Summary of Significant Accounting Policies and Recent Accounting Pronouncements [Table]
Summary of significant accounting policies and recent accounting pronouncements.
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free rate
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
HBV Research Agreement with Indiana University
Research Agreement [Text Block]
Research agreement.
Concentration Risk Benchmark [Domain]
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Research and Development Expense
Research and Development Expense [Member]
Research and Development
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Investments in Marketable Securities
Proceeds from Sale of Productive Assets
Consideration from asset purchase agreement
Proceeds from Sale of Productive Assets, Total
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Schedule of Changes in Contract Liabilities
Research Tax Credit Carryforward [Member]
Research Tax Credit Carryforward
Restructuring Cost and Reserve [Line Items]
Restructuring Cost And Reserve [Line Items]
Securities Purchase Agreement
Securities Purchase Agreement [Member]
Securities Purchase Agreement
Underwritten Offering [Member]
Underwritten Offering
Underwritten Offering
External Program Expenses
External program expenses.
Total external program expenses
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Proceeds from the exercise of stock options
Proceeds from Stock Options Exercised
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Proceeds received from transaction
Upfront equity investment
Sale of Stock, Consideration Received on Transaction
Warrants and pre-funded warrants.
Warrants and Pre-Funded Warrants
Share-Based Payment Arrangement [Abstract]
Gilead Collaboration Agreement, First Amendment
Collaboration Agreement, First Amendment [Member]
Collaboration agreement, first amendment.
Research Agreement [Abstract]
Research agreement.
Assets, Fair Value Disclosure
Total assets measured at fair value
Sale of Stock [Axis]
Sale of Stock
Revenue percentage
Concentration Risk, Percentage
Milestone payment, diligence maintenance fees
Milestone Payment Diligence Maintenance Fees
Milestone payment, diligence maintenance fees.
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash (used in) provided by investing activities
Private Placement [Member]
Private Placement
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Asset impairment and other costs.
Asset Impairment And Other Costs [Member]
Asset Impairment and Other Costs
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Share-based payment awards
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Option, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited
Issuance Of Common Stock Upon Exercise Of Warrants
Issuance of common stock upon exercise of warrants.
Issuance of common stock upon exercise of warrants
Lessee, operating lease, lease not yet commenced, option to extend
Lessee, Operating Lease, Lease Not yet Commenced, Option to Extend
Money Market Funds [Member]
Money market fund
Related and Nonrelated Parties [Domain]
Income Tax Disclosure [Text Block]
Income Taxes
Collaboration term
Collaboration Term
Collaboration term.
Proceeds From Collaborators Option Fee
Proceeds from collaborators, option fee.
Proceeds from option fee
Reimbursable expenses.
Reimbursable Expenses
Reimbursable expenses
Class B Warrants
Class B Warrants
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Option, Outstanding at end of period
Options, Outstanding at beginning of period
A B I Six Two Five Zero [Member]
ABI-6250.
ABI-6250
Income Tax Disclosure [Abstract]
Premium on common stock received
Premium on Common Stock Received
Premium on Common Stock Received
Summary of Operating Loss Carryforwards [Table Text Block]
Summary of Net Operating Loss and Tax Credit Carryforwards
Unrecognized Tax Benefits
Balances as of end of year
Balances as of beginning of year
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Measurement Frequency [Domain]
Measurement Frequency
June Seventeen Two Zero Two Four Warrants [Member]
June seventeen two zero two four warrants.
June 17 2024 warrants
NoInsider Trading Flag
NoInsider Trading Flag.
Nonmonetary Transaction Type [Domain]
Statement of Income Location, Balance [Axis]
Income Statement Location
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Related Party Transaction [Table]
Gilead Sciences, Inc.
Gilead
Gilead Sciences Incorporated [Member]
Gilead sciences incorporated.
Subsequent Event Type [Axis]
Subsequent Event Type
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Fair Value, Recurring [Member]
Recurring
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Other Accrued Expenses
Lessee, Operating Lease, Liability, to be Paid
Total
Regulatory.
Regulatory [Member]
Regulatory
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: present value discount
Federal research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Permanent items
Effective Income Tax Rate Reconciliation Nondeductible Expense Permanent Items
Effective income tax rate reconciliation, nondeductible expense, permanent items.
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Percentage of payroll deductions in ESPP
Equity Components [Axis]
Equity Components
Options expected to vest, Weighted Average Remaining Contractual Term (Years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Number of timepoints of program
Number of Timepoints of Program
Number of timepoints of program.
Nonoperating Income (Expense)
Total other income
Equity Component [Domain]
Equity Component
Asset Class [Axis]
Goodwill and Intangible Assets Disclosure [Abstract]
Capitalized research expense
Income Taxes [Line Items]
Income Taxes [Line Items]
Income Taxes [Line Items]
Document Annual Report
Document Annual Report
Net (accretion) amortization of investments in marketable debt securities
(Accretion) Amortization Of Investments In Marketable Debt Securities
(Accretion) amortization of investments in marketable debt securities.
Net accretion of investments in marketable debt securities
Proceeds From Issuance Or Sale Of Equity Net of Issuance Costs
Proceeds from issuance or sale of equity net of issuance costs.
Net proceeds from issuance of common stock
August 11 2025 Two Warrants
August Eleven Two Zero Two Five Warrants Two[Member]
August Eleven Two Zero Two Five Warrants Two
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Issuance of common stock for settlement of restricted stock units (RSUs) (in shares)
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Number of common stock purchased by employees
Customer [Axis]
Issuance Of Common Stock, Pre-Funded Warrants And Warrants In An Underwritten Offering, Net Of Issuance Cost
Issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance cost.
Issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount
Changes in unrecognized tax benefits
Maximum [Member]
Maximum
Statistical Measurement [Axis]
Statistical Measurement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Options , Exercised
Deferred revenue - long-term
Contract with Customer, Liability, Noncurrent
Deferred revenue from a related party - long-term
Common Stock, Value, Issued
Common stock, $0.001 par value; 150,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 15,855,329 and 7,457,240 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively
Percentage of outstanding voting of common stock held
Percentage of Outstanding Voting of Common Stock Held
Percentage of Outstanding Voting of Common Stock Held
Equipment [Member]
Lab equipment
Deferred Tax Assets, Operating Loss Carryforwards
Federal and state-operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State tax, net of federal income tax effect
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Proceeds from Collaborators
Proceeds received in collaboration agreement
Aggregate non-dilutive capital
Aggregate Non-dilutive Capital
Aaggregate non-dilutive capital
Related Party Transaction [Line Items]
Employee Stock [Member]
Employee Stock Purchase Plan
Entity Registrant Name
Entity Registrant Name
Accounts Receivable, Purchase
Accounts receivable from collaboration
Entity Voluntary Filers
Entity Voluntary Filers
Customer Concentration Risk
Customer Concentration Risk [Member]
Subsequent Events [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Issuance Of Common Stock, Pre-Funded Warrants And Warrants In An Underwritten Offering, Net Of Issuance Costs In Shares
Issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs in shares.
Issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs (in shares)
Income tax expense
Income tax expense
Income Tax Expense (Benefit)
Income tax expense
Measurement Frequency [Axis]
Measurement Frequency
Restructuring costs asset impairment and other costs.
Restructuring costs asset impairment and other costs
Total proceeds
Proceeds from Issuance of Common Stock
Proceeds from the issuance of common stock under ATM equity offering program, net of issuance costs
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Issuance of Common Stock and Warrants in A Registered Direct Offering Value, Net of Issuance Costs
Issuance of common stock and warrants in a registered direct offering value, net of issuance costs.
Issuance of common stock and warrants in a registered direct offering, net of issuance costs
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Payments for Restructuring
Reductions for cash payments
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
A B I One One Seven Nine [Member]
ABI-1179.
ABI-1179
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Represent non cash rent expense.
Noncash Rent Expense
Non-cash rent expense
Common stock subject to purchase under employee stock purchase program.
Common Stock Subject To Purchase Under Employee Stock Purchase Program [Member]
Common stock subject to purchase under ESPP
Assets
Total assets
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options Vested and Exercisable, Weighted Average Remaining Contractual Term (Years)
Income Statement [Abstract]
Stock Outstanding During Period Shares Reverse Stock Splits
Stock outstanding during period shares reverse stock splits.
Common stock shares outstanding due to reverse stock split
Restructuring Cost [Table]
Schedule Of Restructuring And Related Costs [Table]
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decreases related to prior year tax positions
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Number of share Purchased
Sale of Stock, Number of Shares Issued in Transaction
Number of shares sold
Stock Issued During Period, Shares, New Issues
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)
Number of shares sold
Lease, Cost [Abstract]
Lease cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of awards vested and settled
Vested
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Variable Interest Entities
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share - diluted
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Segment Expenses and Other Segment Items
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Percent
June 2024 Registered Direct Offering and June 2024 Private Placement
Registered Direct Offering and Private Placement [Member]
Registered direct offering and private placement.
City Area Code
City Area Code
Auditor Name
Auditor Name
Cash and cash equivalent gross unrealized gain.
Cash And Cash Equivalent Gross Unrealized Gain
Gross Unrealized Gain
Potential proceeds from collaboration extension fees
Potential Proceeds from Collaboration Extension Fees
Potential proceeds from collaboration extension fees.
Sale consideration receivable.
Sale Consideration Receivable
Consideration due
Collaborative and License Arrangement Disclosure.
Collaborative And License Arrangement Disclosure [Text Block]
Collaboration Agreements
Counterparty Name
Counterparty Name [Domain]
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Federal research and development tax credits
Variable Lease, Cost
Variable lease cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Total intrinsic value of awards vested and settled
Issuance of common stock under Employee Stock Purchase Plan (ESPP)
Stock Issued During Period, Value, Employee Stock Purchase Plan
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term - operating leases
June Sixteen Two Zero Two Four Warrants [Member]
June Sixteen Two Zero Two Four Warrants [Member]
June 16 2024 warrants
Segment Reporting Information [Line Items]
Reverse stock split ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Options, Forfeited
Lease, Cost
Total lease cost, net
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Gillead Collaboration Agreement
Option, License and Collaboration Agreement
Option, License and Collaboration Agreement [Member]
Option, license and collaboration agreement.
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash and cash equivalents at the beginning of the year
Cash and cash equivalents at the end of the year
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents
Class of Warrant or Right Exercised
Warrant exercised
Class of warrant or right exercised.
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
The value of common stock authorized to issue in a public offering.
Initial Public Offering Value Of Shares Authorized
Initial public offering value of shares authorized
Available for sale debt securities accumulated gross unrealized loss before tax current.
Available for Sale Debt Securities Accumulated Gross Unrealized Loss before Tax Current
Gross Unrealized Loss, Short-term marketable securities
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate - operating leases
Operating Lease, Liability, Noncurrent
Operating lease liabilities - long-term
Fair Value, Inputs, Level 1 [Member]
Level 1
Issuance of Common Stock and Warrants in A Registered Direct Offering, Net of Issuance Costs
Issuance of common stock and warrants in a registered direct offering, net of issuance costs.
Issuance of common stock and warrants in a registered direct offering, net of issuance costs (in shares)
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Gilead Equity Agreements
Equity Agreements [Member]
Equity agreements.
Lease, Cost [Table Text Block]
Schedule of Quantitative Information of Operating Leases
Non-taxable or nondeductible items:
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Auditor Location
Deferred Income Tax Liabilities, Net
Deferred tax liabilities
Warrant Expiration Term
Warrant expiration term.
Warrant expiration term
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Summary of Warrants and Pre-funded Warrants to Purchase Shares of Common Stock Issued and Outstanding
Nonoperating Income (Expense) [Abstract]
Other income
Accrued interest receivable
Accured Interest Receivable
Accured Interest Receivable
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Corporate Debt Securities [Member]
Corporate debt securities
Income Tax Jurisdiction [Domain]
Income Tax Authority
Debt Securities, Available-for-Sale [Table]
Entity Interactive Data Current
Entity Interactive Data Current
Research and Development, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Increase (Decrease) in Contract with Customer, Liability
Contract liabilities recognized
Deferred revenue from a related party
Statement of Income Location, Balance [Domain]
Income Statement Location
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities
Option Indexed to Issuer's Equity, Type [Domain]
Option Indexed to Issuer's Equity, Type
Entity Tax Identification Number
Entity Tax Identification Number
Closing bid price of stock
Share Price
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Proceeds from maturities of marketable securities
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of Business
Interest Income, Other
Interest and other income, net
Interest and other income, net
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Gross proceeds from issuance of common stock and warrant
Local Phone Number
Local Phone Number
Related Party Transaction [Domain]
Debt Securities, Realized Gain (Loss)
Realized gain on investments in marketable debt securities
Concentration of risk.
Concentration Of Risk Policy Policy [Text Block]
Concentrations of Risk
Short-Term Lease, Cost
Short-term lease cost
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Auditor Opinion [Text Block]
Auditor Opinion
Schedule of restructuring charges.
Schedule Of Restructuring Charges Table [Text Block]
Schedule of Restructuring Charges
Restructuring Costs, Total
Restructuring Costs
Restructuring costs
Restructuring and related cost incurred cost benefit
Restructuring And Related Cost Incurred Cost Benefit
Restructuring costs incurred
Restructuring charges
Accounting Policies [Abstract]
Percentage of premium to weighted average price immediately prior to date of purchase
Percentage of Premium to Weighted Average Price Immediately Prior to Date of Purchase
Percentage of premium to weighted average price immediately prior to date of purchase.
Contract with Customer, Performance Obligation Satisfied in Previous Period
Performance obligations satisfied in previous period
Reduction in research and development expense.
Reduction In Research And Development Expense
Reduction in research and development expense
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration revenue from a related party
Revenue recognized
Revenue recognized
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Lease expiration, month and year
Lease Expiration, Month And Year
Lease expiration, month and year.
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Commercial Paper [Member]
Commercial paper
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Maximum shares available for purchase by employees (in shares)
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation expense expected to be recognized, term
Office Equipment [Member]
Office equipment
Accrued Professional Fees, Current
Accrued professional fees and other
Cash, cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
Employee and Contractor Related Expenses
Employee and contractor-related expenses.
Employee and contractor-related expenses
Entity Emerging Growth Company
Entity Emerging Growth Company
Employee severance and related benefits.
Employee Severance And Related Benefits [Member]
Employee Severance and Related Benefits
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name