Entity Address, City or Town
Entity Address, City or Town
Terminated Employees
Employee Severance [Member]
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
Effective Income Tax Rate of Provision for Income Taxes
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Operating lease right-of-use assets
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Deferred tax liabilities, operating lease right-of-use assets.
Level 1
Fair Value, Inputs, Level 1 [Member]
Schedule of Other Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Federal
Domestic Tax Authority [Member]
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs
Stock Issued During Period, Value, New Issues
Research and Development Expense and Accruals
Research and Development Expense, Policy [Policy Text Block]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Foreign federal income tax expense (benefit).
Foreign
Foreign Federal Income Tax Expense Benefit
Performance obligations satisfied in previous period
Contract with Customer, Performance Obligation Satisfied in Previous Period
Amendment Flag
Amendment Flag
Total fair value of awards vested and settled
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Shares reserved for issuance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Subsequent Event Type
Subsequent Event Type [Domain]
Potential milestone payments
Potential Milestone Payments
Potential Milestone Payments.
Executive Officer
Executive Officer [Member]
Operating lease, right-of-use asset
Operating lease right-of-use (ROU) assets
Operating Lease, Right-of-Use Asset
Short-term marketable securities
Short-Term Investments [Abstract]
Gross Unrealized Gain
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Gain
Cash equivalents at carrying value and available for sale debt securities gross unrealized gain.
Proceeds from sale of marketable securities
Proceeds from Sale of Debt Securities, Available-for-Sale
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
Less: present value discount
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Net Loss per Share
Earnings Per Share, Policy [Policy Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Statement [Table]
Statement [Table]
Operating lease liabilities - long-term
Operating Lease, Liability, Noncurrent
Operating cash flows from operating leases
Operating Lease, Payments
Number of common stock purchased by employees
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Operating segments (in segments)
Number of Operating Segments
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Restructuring Charges, Total
Costs incurred
Restructuring Charges
Milestones and Research Agreements
Milestones And Research Agreements [Text Block]
Milestones and Research Agreements
Common stock, capital shares reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Auditor Firm ID
Auditor Firm ID
Beginning of period
Ending of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Gain on the sale of Microbiome assets
Gain (Loss) on Disposition of Business
Income Tax Authority
Income Tax Authority [Domain]
Employee Stock Purchase Plan
Employee Stock [Member]
Wind- own of microbiome program.
Wind Down Of Microbiome Program [Member]
Wind-down of Microbiome Program
Employee-related Liabilities, Current, Total
Accrued compensation
Employee-related Liabilities, Current
Leases
Lessee, Operating Leases [Text Block]
Options
Share-Based Payment Arrangement, Option [Member]
Weighted-average remaining lease term - operating leases
Operating Lease, Weighted Average Remaining Lease Term
Total liabilities and stockholders' equity
Liabilities and Equity
Plan Name
Plan Name [Domain]
Total intrinsic value of awards vested and settled
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Gross Unrealized Loss, Long-term marketable securities
Available For Sale Debt Securities Accumulated Gross Unrealized Loss before Tax Noncurrent
Available for sale debt securities accumulated gross unrealized loss before tax noncurrent.
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Percentage of workforce reduced
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Development and Regulatory
Development And Regulatory [Member]
Development and regulatory.
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Income Statement [Abstract]
Uncertain tax positions
Effective Income Tax Rate Reconciliation Uncertain Tax Positions Rate
Effective income tax rate reconciliation uncertain tax positions rate.
Outside of United States
Non-US [Member]
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Return to provision adjustments
Effective Income Tax Rate Reconciliation Return To Provision Adjustments
Effective income tax rate reconciliation return to provision adjustments.
Nature of Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Impairment of goodwill
Effective Income Tax Rate Reconciliation Impairment Of Goodwill
Effective income tax rate reconciliation impairment of goodwill.
Options, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Sale of Stock
Sale of Stock [Domain]
Total current liabilities
Liabilities, Current
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Recurring
Fair Value, Recurring [Member]
Short-term lease cost
Short-Term Lease, Cost
Other Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Income Taxes
Income Tax, Policy [Policy Text Block]
Gross Unrealized Loss
Cash And Cash Equivalent Gross Unrealized Loss
Cash and cash equivalent gross unrealized loss.
Schedule of Accrued Restructuring Charges
Schedule Of Accrued Restructuring Charges Table [Text Block]
Schedule of accrued restructuring charges.
Contract liabilities recognized
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Collaboration Agreement [Abstract]
Collaboration Agreement
Percentage of payroll deductions in ESPP
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Other Assets
Other Noncurrent Assets [Member]
Deferred Tax Liabilities, Net, Total
Net deferred tax liability
Deferred Tax Liabilities, Net
Operating lease liabilities
Deferred Tax Assets Operating Lease Liabilities
Deferred tax assets operating lease liabilities.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule of Deferred Income Tax Benefit
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Weighted-average discount rate - operating leases
Operating Lease, Weighted Average Discount Rate, Percent
Entity Small Business
Entity Small Business
Microbiome Purchase Agreement
Microbiome Purchase Agreement [Member]
Microbiome purchase agreement.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Investments
Investments [Domain]
Restructuring and Related Activities [Abstract]
Award Date [Domain]
Total current assets
Assets, Current
Property, Plant and Equipment
Property, Plant and Equipment [Line Items]
Schedule of Changes in Contract Liabilities
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Weighted average common shares and pre-funded warrants outstanding - basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
City Area Code
City Area Code
Option, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Option, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Share-Based Payment Arrangement [Abstract]
Total liabilities
Liabilities
Document Period End Date
Document Period End Date
Asset-backed securities
Asset-Backed Securities [Member]
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Weighted-average grant-date fair value of options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Market-based Vesting Conditions
Share-Based Payment Arrangement, Tranche One [Member]
Contract with customer, liability, noncurrent
Deferred revenue
Contract with Customer, Liability, Noncurrent
Statistical Measurement
Statistical Measurement [Axis]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Interest and other income, net
Interest Income, Other
Restructuring costs
Restructuring Costs
Restructuring Costs, Total
Total assets
Assets
Expiration Years
Operating Loss Carry Forwards Expiration Period
Expiration date of each operating loss carry forward
State:
Current, Deferred And Foreign State Local Tax Expense Benefit [Abstract]
Current, deferred and foreign state local tax expense benefit.
State
State and Local Jurisdiction [Member]
Dilutive effect of securities
Dilutive Securities, Effect on Basic Earnings Per Share
Dilutive Securities, Effect on Basic Earnings Per Share, Total
Net loss per share - diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Collaboration revenue
Revenue from Contract with Customer, Including Assessed Tax
Document Fiscal Period Focus
Document Fiscal Period Focus
Office equipment
Office Equipment [Member]
Accounts receivable from collaboration
Increase (Decrease) in Accounts Receivable
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding
Preferred Stock, Value, Issued
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Option Indexed to Issuer's Equity, Type
Option Indexed to Issuer's Equity, Type [Axis]
Operating Lease, Liability, Total
Operating lease liabilities
Operating lease, liability
Operating Lease, Liability
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Statement of Financial Position [Abstract]
Indefinite-lived intangible assets impairment charges
Impairment of Intangible Assets, Indefinite-Lived (Excluding Goodwill)
Entity File Number
Securities Act File Number
Statement of Cash Flows [Abstract]
Sublease income
Sublease Income
Number of pre-funded warrants sold to purchase of common stock
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Performance milestone payment
Performance Milestone Payment
Performance milestone payment.
Schedule of Collaboration Revenue Recognized with the Period
Schedule Of Collaboration Revenue Recognized With Period Table [Text Block]
Schedule of Collaboration revenue recognized with the period
Geographical [Domain]
Statistical Measurement
Statistical Measurement [Domain]
Fair Value
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Estimated Fair Value
Cash equivalents at carrying value and available for sale debt securities estimated fair value.
Statement of Stockholders' Equity [Abstract]
Sale of Stock
Sale of Stock [Axis]
Purchase price after discount (in percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Auditor Location
Auditor Location
Other accrued expenses
Increase (Decrease) in Other Accrued Liabilities
Legal Entity [Axis]
Schedule of Quantitative Information of Operating Leases
Lease, Cost [Table Text Block]
Short-term marketable securities
Short Term Marketable Securities [Member]
Short term marketable securities.
Subsequent Events [Abstract]
Option, Expired
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Other comprehensive loss
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Foreign state and local income tax expense (benefit).
Foreign
Foreign State And Local Income Tax Expense Benefit
Options Vested and Exercisable, Weighted Average Remaining Contractual Term (Years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Net Proceeds
Proceeds from the issuance of common stock under ATM equity offering program, net of issuance costs
Proceeds from Issuance of Common Stock
Restructuring one-time termination Cost
Restructuring one time termination cost.
Deferred income tax benefit
Deferred Income Tax Expense (Benefit)
Deferred Income Tax Expense (Benefit), Total
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Antidilutive Securities
Antidilutive Securities [Axis]
Arbutus Biopharma Agreement
Arbutus Agreement [Member]
Arbutus agreement.
Summary of Warrants to Purchase Shares of Company's Common Stock
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
FDA approved products (in products)
Number Of Approved Products
Represents the number of approved products.
Number of common stock to be issued per offering
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Per Employee
Share based compensation arrangement by share based payment award number of shares per employee.
Subsequent Event
Subsequent Events [Text Block]
Weighted average common shares and pre-funded warrants outstanding - diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Gross Unrealized Gain, Short-term marketable securities
Available for Sale Debt Securities Accumulated Gross Unrealized Gain before Tax Current
Available for sale debt securities accumulated gross unrealized gain before tax current.
Cash equivalents
Cash Equivalents [Member]
Unrecognized stock-based compensation expense
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
U.S and foreign corporate debt securities
Corporate Debt Securities [Member]
Gain (Loss) on Disposition of Assets, Total
Gain on sale assets
Gain (Loss) on Disposition of Assets
General and Administrative
General and Administrative Expense [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
U.S. and foreign commercial paper
Commercial Paper [Member]
Current Fiscal Year End Date
Current Fiscal Year End Date
Investment Type
Investment Type [Axis]
Exercise price
Share Based Compensation Arrangement Fair Value Assumptions Exercise Price
Share based compensation arrangement fair value assumptions exercise price.
Depreciation, Total
Depreciation
Depreciation
Financial Instruments
Financial Instruments [Domain]
Research and development funding charges
Research And Development Funding Charges
Research and development funding charges.
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash and cash equivalents at the beginning of the period
Cash and cash equivalents at the end of the period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Accrued research and development expenses
Increase Decrease In Accrued Research And Development Expenses
Increase (decrease) in accrued research and development expenses.
Other assets
Other Assets, Noncurrent
Entity Address, Address Line One
Entity Address, Address Line One
License agreement term
Licenses Agreement Term
License agreement term.
Document Annual Report
Document Annual Report
Accrued expenses:
Accrued Liabilities, Current [Abstract]
2020 ATM
2020 At the Market Offerings
Two Thousand And Twenty At The Market Offerings [Member]
Two thousand and twenty at the market offerings.
Subsidiary Sale Of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Investments in Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Income Tax Expense (Benefit), Total
Income tax benefit
Income tax benefit
Income Tax Expense (Benefit)
Capitalized and amortized costs period.
Capitalized And Amortized Costs Period
Capitalized and amortized costs period
Income Taxes
Income Tax Disclosure [Text Block]
Vesting [Axis]
Preferred stock, shares issued
Preferred Stock, Shares Issued
Balance Sheet Location
Balance Sheet Location [Domain]
Other accrued expenses
Other Accrued Liabilities, Current
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Income Tax Disclosure [Abstract]
Collaborative Arrangement
Collaborative Arrangement [Member]
Number of shares sold
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)
Stock Issued During Period, Shares, New Issues
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Issuance of common stock for settlement of restricted stock units (RSUs)
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Goodwill and Intangible Assets Disclosure [Abstract]
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Auditor Name
Auditor Name
2018 ESPP
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
TwoThousandEighteenEmployeeStockPurchasePlanMember
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Incremental costs
Incremental Costs
Incremental costs.
Equity [Abstract]
Amounts included in deferred revenue at the beginning of the period
Contract with Customer, Liability, Revenue Recognized
Option, Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Loss from operations
Operating Income (Loss)
Additional paid-in capital
Additional Paid in Capital, Common Stock
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)
Stock Issued During Period, Shares, Employee Stock Ownership Plan
Consideration from asset purchase agreement, entitled to receive
Consideration Of Assets Sale Agreement To Be Received
Consideration of assets sale agreement to be received.
Stock-based compensation arrangement by share-based payment award, requisite service period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Proceeds from the issuance of common stock under ESPP
Proceeds From Issuance Of Common Stock Under Employee Stock Purchase Plan
Proceeds from issuance of common stock under employee stock purchase plan.
Accrued professional fees and other
Accrued Professional Fees, Current
Entity Filer Category
Entity Filer Category
Employee severance and related benefits
Option Indexed to Issuer's Equity, Type
Option Indexed to Issuer's Equity, Type [Domain]
Total operating expenses
Operating Expenses
Entity Current Reporting Status
Entity Current Reporting Status
Current
Current State and Local Tax Expense (Benefit)
Impairment charges of goodwill and indefinite-lived assets
Goodwill and Intangible Asset Impairment, Total
Impairment of goodwill and indefinite-lived intangible asset
Goodwill and Intangible Asset Impairment
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Options vested and exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Marketable securities - short-term
Fair Value, Short-term marketable securities
Short-term marketable securities
Stockholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Total stockholders' equity
Balance
Balance
Stockholders' Equity Attributable to Parent
Accumulated Other Comprehensive Loss
AOCI Attributable to Parent [Member]
Short-term marketable securities
Short-Term Investments [Member]
Available for sale securities maturity term
Debt Securities, Available-for-Sale, Term
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Schedule of Investments in Marketable Available-for-Sale Securities
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Accrued restructuring charges
Accrued balance
Accrued balance
Accrued Restructuring Charges Current
Accrued restructuring charges current.
Income Statement Location
Income Statement Location [Axis]
Forfeited
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Common stock, $0.001 par value; 150,000,000 and 100,000,000 shares authorized as of December 31, 2022 and December 31, 2021, respectively; 48,894,973 and 48,120,437 shares issued and outstanding as of December 31, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Lab equipment
Equipment [Member]
Equity Components
Equity Components [Axis]
Accrued research and development expenses
Accrued Research And Development Expenses Current
Accrued research and development expenses current.
Gross Unrealized Loss
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Loss
Cash equivalents at carrying value and available for sale debt securities gross unrealized loss.
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Leases [Abstract]
Contract with Customer, Liability, Total
Contract liability/deferred revenue
Balance at Beginning of Period
Balance at End of Period
Contract with Customer, Liability
Variable Interest Entities
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Impairment, Intangible Asset, Indefinite-Lived (Excluding Goodwill), Statement of Income or Comprehensive Income [Extensible Enumeration]
Operating expenses
Operating Expenses [Abstract]
Percentage of corporate alternative minimum tax
Percentage of corporate alternative minimum tax
Percentage of corporate alternative minimum tax.
Current
Current Federal Tax Expense (Benefit)
Proceeds from maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Revenue Recognition and Accounts Receivable from Collaborations
Revenue [Policy Text Block]
Expected term (years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase decrease in operating lease liabilities.
Entity Voluntary Filers
Entity Voluntary Filers
Deferred
Deferred Federal Income Tax Expense (Benefit)
Research Tax Credit Carryforward
Research Tax Credit Carryforward [Member]
Total Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Retirement Benefits [Abstract]
Document Transition Report
Document Transition Report
Number of shares sold
Sale of Stock, Number of Shares Issued in Transaction
Total assets measured at fair value
Assets, Fair Value Disclosure
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Other Risks And Uncertainties
Other Risks And Uncertainties Policy [Text Block]
Other risks and uncertainties.
Total other income
Nonoperating Income (Expense)
Depreciation, Depletion and Amortization, Total
Depreciation and amortization
Depreciation, Depletion and Amortization
Issuance of common stock for settlement of restricted stock units (RSUs) (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Maximum number of common stock to be issued per offering
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accounts receivable from collaboration
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts receivable from collaboration
Accounts Receivable, after Allowance for Credit Loss, Current
Receivable from sale of microbiome assets included in prepaid expenses and other current assets.
Receivable From Sale Of Microbiome Assets Included In Prepaid Expenses And Other Current Assets
Receivable from sale of Microbiome assets included in prepaid expenses and other current assets
Investments in Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Milestone and Research Agreements:
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Deferred
Deferred State and Local Income Tax Expense (Benefit)
Amortized Cost, Long-term marketable securities
Debt Securities, Available-for-Sale, Amortized Cost, Noncurrent
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Operating lease liabilities - short-term
Operating Lease, Liability, Current
Federal:
Current Deferred And Foreign Federal Local Tax Expense Benefit [Abstract]
Current deferred and foreign federal local tax expense benefit.
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Restructuring costs reversal
Restructuring costs reversal of stock-based compensation expense
Deferred Tax Assets, Operating Loss Carryforwards, Total
Federal and state-operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Cash equivalents
Cash Equivalents At Fair Value [Abstract]
Cash equivalents at fair value.
Entity Registrant Name
Entity Registrant Name
Amortized Cost
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
U.S and foreign corporate debt securities
US Government Agencies Debt Securities [Member]
Share-Based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Award Type
Award Type [Domain]
Statement [Line Items]
Statement [Line Items]
State, current, deferred and foreign income tax expense benefit
State, Current, Deferred And Foreign Income Tax Expense Benefit
State, current, deferred and foreign income tax expense benefit.
Upfront cash payment received
Upfront Cash Payment Received
Upfront cash payment received.
Title of 12(b) Security
Title of 12(b) Security
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Restructuring Cost And Reserve [Line Items]
Restructuring Cost and Reserve [Line Items]
Common Stock
Common Stock [Member]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Equity Component
Equity Component [Domain]
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-Sale
Loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Entity Address, State or Province
Entity Address, State or Province
Geographical [Axis]
Milestones And Research Agreements [Abstract]
Milestones and Research Agreements
Net increase (decrease) in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Document Type
Document Type
Entity Shell Company
Entity Shell Company
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Fair value assets transfers between level 1, level 2 or level 3
Fair Value Assets Between Levels Transfers Amount
Fair value assets between levels transfers amount.
Gross Unrealized Gain, Long-term marketable securities
Available For Sale Debt Securities Accumulated Gross Unrealized Gain before Tax Noncurrent
Available for sale debt securities accumulated gross unrealized gain before tax noncurrent.
Proceeds from the sale of Microbiome assets
Proceeds from Divestiture of Businesses
Door Agreement
Doors Agreement [Member]
Door agreement.
Total fair value of awards
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Amount
The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.
Security Exchange Name
Security Exchange Name
Goodwill and Indefinite-Lived Intangible Asset
Goodwill and Intangible Assets, Policy [Policy Text Block]
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Summary of Significant Accounting Policies and Recent Accounting Pronouncements
Significant Accounting Policies [Text Block]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Unrecognized stock-based compensation expense expected to be recognized, term
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Options Outstanding, Weighted Average Remaining Contractual Term (Years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Amortized Cost, Short-term marketable securities
Debt Securities, Available-for-Sale, Amortized Cost, Current
Operating lease cost
Operating Lease, Cost
RSUs
Restricted Stock Units (RSUs) [Member]
Schedule of Maturities Operating Lease Liabilities
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Activity Related to Gross Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Amortized Cost
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Amortized Cost
Cash equivalents at carrying value and available for sale debt securities amortized cost.
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Summary of Stock Option Activity and Related Information
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Accounting Pronouncements to Be Adopted
New Accounting Pronouncements, Policy [Policy Text Block]
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Level 2
Fair Value, Inputs, Level 2 [Member]
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Increases related to current year tax positions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Commitments and contingencies
Commitments and Contingencies
Common stock, shares issued
Common Stock, Shares, Issued
U.S. treasury securities
US Treasury Securities [Member]
Income Taxes [Table]
Income Taxes [Table]
Income taxes.
Minimum
Minimum [Member]
Summary of Restructuring Costs
Restructuring and Related Costs [Table Text Block]
BeiGene agreement.
BeiGene Agreement
Bei Gene Agreement [Member]
Leases
Lessee, Leases [Policy Text Block]
Options vested and exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Total accrued expenses
Accrued expenses
Accrued Liabilities, Current
Stockholders' equity
Stockholders' Equity Attributable to Parent [Abstract]
State taxes, net of federal tax benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Schedule Of Available For Sale Securities [Table]
Schedule of Available-for-Sale Securities [Table]
Entity Address, Address Line Two
Entity Address, Address Line Two
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Federal, current, deferred and foreign income tax expense benefit
Federal Current, Deferred And Foreign Income Tax Expense Benefit
Federal current, deferred and foreign income tax expense benefit.
Award Type
Award Type [Axis]
Subsequent Event
Subsequent Event [Member]
Total deferred tax assets
Deferred Tax Assets, Gross
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Other income
Nonoperating Income (Expense) [Abstract]
Research and Development Expense, Total
Research and development expense
Research and development
Research and Development Expense
Total
Lessee, Operating Lease, Liability, to be Paid
Restructuring Type
Restructuring Type [Axis]
Decreases related to prior year tax positions
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Award Date [Axis]
Entity Central Index Key
Entity Central Index Key
Milestone payment, diligence maintenance fees.
Milestone Payment Diligence Maintenance Fees
Milestone payment, diligence maintenance fees
Valuation allowance increased
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Reductions for cash payments
Payments for Restructuring
Weighted Average Fair Value Per RSU at Grant Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Intrinsic Value, Amount Per Share [Abstract]
Asset Impairment and Other Costs
Asset Impairment And Other Costs [Member]
Asset impairment and other costs.
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Accounting Policies [Abstract]
Investments, Debt and Equity Securities [Abstract]
Additions
Contract With Customer Liability In Additions
Contract with customer liability in additions.
Investments in marketable securities:
Debt Securities, Available-for-Sale [Line Items]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Cash in deposit accounts
Deposits, Savings Deposits
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
U.S. and foreign commercial paper.
U S And Foreign Commercial Paper [Member]
U.S. and foreign commercial paper
Silicon Valley Bank
Silicon Valley Bank Member
Silicon Valley Bank.
Measurement Frequency
Measurement Frequency [Axis]
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Maximum shares available for purchase by employees (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Subsequent Event [Table]
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Options, Outstanding at beginning of period
Option, Outstanding at end of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Agreed to pay maximum amount development and regulatory costs
Agreed To Pay Maximum Amount Development And Regulatory Costs
Agreed to pay maximum amount development and regulatory costs.
Summary of Net Operating Loss and Tax Credit Carryforwards
Summary of Operating Loss Carryforwards [Table Text Block]
Research and Development
Research and Development Expense [Member]
Prepaid Expenses and Other Current Assets
Prepaid Expenses and Other Current Assets [Member]
Total lease cost, net
Lease, Cost
ROU assets exchanged for new operating lease liabilities
Operating lease liabilities arising from obtaining ROU assets
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Issuance of common stock under Employee Stock Purchase Plan (ESPP)
Stock Issued During Period, Value, Employee Stock Ownership Plan
Accumulated Deficit
Retained Earnings [Member]
Tax Credit Carryforward, Name
Tax Credit Carryforward, Name [Domain]
Regulatory
Regulatory [Member]
Regulatory.
Money market fund
Money Market Funds [Member]
Income taxes benefit
Effective Income Tax Rate Reconciliation, Percent
Compensation expense:
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Gain (Loss) on Disposition of Property Plant Equipment, Total
Loss on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Total property and equipment
Property, Plant and Equipment, Gross
Bei Gene Limited
Bei Gene Limited [Member]
BeiGene, Limited.
Entity Interactive Data Current
Entity Interactive Data Current
Entity Public Float
Entity Public Float
Income Taxes [Line Items]
Income Taxes [Line Items]
Income Taxes [Line Items]
Issuance of common stock upon cashless exercise of pre-funded warrants (in shares)
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants Shares
Issuance of common stock upon cashless exercise of pre-funded warrants shares.
Supplemental non-cash investing and financing activities
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Leasehold improvement
Leasehold Improvements [Member]
Net proceeds
Net proceeds from the issuance of common stock through equity plans
Proceeds from Issuance Initial Public Offering
Local Phone Number
Local Phone Number
Statutory federal income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Balances as of beginning of year
Balances as of end of year
Unrecognized Tax Benefits
Granted in August 2022
Granted In August Two Thousand Twenty Two [Member]
Granted in August 2022.
Schedule of Earnings Per Share, Basic and Diluted
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Employees Including Executive Officers
Employees Including Executive Officers [Member]
Employees including executive officers.
Share-based Compensation Arrangement by Share-based Payment Award
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Options vested and exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Option, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Income Statement Location
Income Statement Location [Domain]
Option, Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Property, Plant and Equipment [Abstract]
Outstanding awards
Beginning of period
Ending of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Balance (in shares)
Balance (in shares)
Shares, Outstanding
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Options, Outstanding at beginning of period
Option, Outstanding at end of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Document Fiscal Year Focus
Document Fiscal Year Focus
Remeasurement of lease liabilities arising from modification of ROU assets
Remeasurement Of Lease Liabilities Arising From Modification Of Right Of Use Assets
Remeasurement of lease liabilities arising from modification of right of use assets.
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Uncertain tax positions, income tax interest or penalties accrued
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Schedule of Fair Value of Financial Assets
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Public Offering
Public Offering [Member]
PublicOffering
Proceeds from Sale of Productive Assets, Total
Consideration from asset purchase agreement
Proceeds from Sale of Productive Assets
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Sales Milestone Payments
Net Sales Milestone Payments [Member]
Net sales milestone payments.
Antios Agreement
Antios Agreement [Member]
Antios agreement.
Vesting [Domain]
Net loss per share - basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Weighted Average Exercise Price Per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Employee Benefit Plan
Compensation and Employee Benefit Plans [Text Block]
ASSETS
Assets [Abstract]
Restructuring costs asset impairment and other costs
Restructuring costs asset impairment and other costs.
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Financial Instrument
Financial Instrument [Axis]
Non-cash rent expense
Noncash Rent Expense
Represent non cash rent expense.
Common stock subject to purchase under ESPP
Common Stock Subject To Purchase Under Employee Stock Purchase Program [Member]
Common stock subject to purchase under employee stock purchase program.
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Schedule Of Restructuring And Related Costs [Table]
Schedule of Restructuring and Related Costs [Table]
Long-term marketable securities
Long Term Marketable Securities [Member]
Long term marketable securities.
Capitalized research expense
Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities and Equity [Abstract]
Potential milestone payment
Purchase Commitment, Remaining Minimum Amount Committed
Property and Equipment, Net
Property, Plant and Equipment, Policy [Policy Text Block]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Income Tax Authority
Income Tax Authority [Axis]
Type of Restructuring
Type of Restructuring [Domain]
Summary of Restricted Stock Units and Related Information
Nonvested Restricted Stock Shares Activity [Table Text Block]
Deferred tax asset, net of valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Current assets
Assets, Current [Abstract]
Pre-funded warrants exercisable price per share
Exercise Price per Share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Long-term marketable securities
Long-Term Investments [Abstract]
Debt Securities, Available-for-Sale, Noncurrent
Fair Value, Long-term marketable securities
Long-term marketable securities
Components of Deferred Taxes
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Gross Unrealized Gain
Cash And Cash Equivalent Gross Unrealized Gain
Cash and cash equivalent gross unrealized gain.
Increases related to prior year tax positions
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Defined Contribution Plan, Employer Discretionary Contribution Amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
Payables and Accruals [Abstract]
Consideration due
Sale Consideration Receivable
Sale consideration receivable.
Measurement Frequency
Measurement Frequency [Domain]
Amortization of investments In marketable debt securities.
Amortization Of Investments In Marketable Debt Securities
Net amortization of investments in marketable debt securities
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Collaboration Agreements
Collaborative And License Arrangement Disclosure [Text Block]
Collaborative and License Arrangement Disclosure.
Lease cost
Lease, Cost [Abstract]
Entity [Domain]
Restructurings
Restructuring and Related Activities Disclosure [Text Block]
Cover [Abstract]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Uncertain tax positions, income tax interest or penalties incurred
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Options, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Vested
Number of awards vested and settled
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Goodwill impairment charge
Goodwill, Impairment Loss
Current liabilities
Liabilities, Current [Abstract]
Maximum
Maximum [Member]
Unrealized loss on marketable securities
Unrealized loss on marketable debt securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Schedule of Recognized Stock-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Initial public offering value of shares authorized
Initial Public Offering Value Of Shares Authorized
The value of common stock authorized to issue in a public offering.
Net cash provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Issuance of common stock upon cashless exercise of pre-funded warrants
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants
Issuance of common stock upon cashless exercise of pre-funded warrants.
Restructurings Charges
Costs Associated with Exit or Disposal Activities or Restructurings, Policy [Policy Text Block]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Options exercised
Issuance of common stock upon exercise of stock options ( in shares )
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Gross Unrealized Loss, Short-term marketable securities
Available for Sale Debt Securities Accumulated Gross Unrealized Loss before Tax Current
Available for sale debt securities accumulated gross unrealized loss before tax current.
Goodwill and Indefinite-Lived Intangible Asset Impairment
Goodwill and Intangible Assets Disclosure [Text Block]
Level 3
Fair Value, Inputs, Level 3 [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Estimated useful lives of property and equipment
Property, Plant and Equipment, Useful Life
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Collaboration revenue recognized in the period from
Collaboration Revenue Recognized In Period [Abstract]
Collaboration revenue recognized in period [Abstract]
Deferred tax assets:
Deferred Tax Assets, Net [Abstract]
Common stock, shares authorized
Common Stock, Shares Authorized
Trading Symbol
Trading Symbol
Title of Individual
Title of Individual [Domain]
Subsequent Event Type
Subsequent Event Type [Axis]
Other
Deferred Tax Assets, Other
Performance conditions not yet Met
Balance Sheet Location
Balance Sheet Location [Axis]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Risk-free rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Proceeds from Sale of Property, Plant, and Equipment, Total
Proceeds from sale of property and equipment
Proceeds from Sale of Property, Plant, and Equipment
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Plan Name
Plan Name [Axis]
Deductions
Contract With Customer Liability In Deduction
Contract with customer liability in deduction.
Title of Individual
Title of Individual [Axis]
Concentrations of Risk
Concentration Of Risk Policy Policy [Text Block]
Concentration of risk.
Schedule of Restructuring Charges
Schedule Of Restructuring Charges Table [Text Block]
Schedule of restructuring charges.
Restructuring charges
Restructuring costs incurred
Restructuring And Related Cost Incurred Cost Benefit
Restructuring and related cost incurred cost benefit
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Variable lease cost
Variable Lease, Cost
Reduction in research and development expense
Reduction In Research And Development Expense
Reduction in research and development expense.
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Number of pre-funded warrants exercised
Number Of Warrants Exercised
Number of warrants exercised.
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Option, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Antidilutive securities excluded from computation of loss per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Fair Value
Total cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Employee Severance and Related Benefits
Employee Severance And Related Benefits [Member]
Employee severance and related benefits.
Other assets
Increase (Decrease) in Other Noncurrent Assets