Entity Central Index Key
Cash and cash equivalent gross unrealized gain.
Cash and cash equivalent gross unrealized loss.
Cover [Abstract]
Document Type
Document Type
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Document Period End Date
Document Period End Date
Entity File Number
Entity File Number
Entity Registrant Name
Entity Registrant Name
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Amendment Flag
Amendment Flag
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Current Reporting Status
Entity Current Reporting Status
Entity Interactive Data Current
Entity Interactive Data Current
Entity Filer Category
Entity Filer Category
Trading Symbol
Trading Symbol
Security Exchange Name
Security Exchange Name
Title of 12(b) Security
Security12b Title
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Entity Shell Company
Entity Shell Company
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Small Business
Entity Small Business
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Public Float
Entity Public Float
Auditor Name
Auditor Name
Auditor Firm ID
Auditor Firm Id
Auditor Location
Auditor Location
Accrued research and development expenses current.
Statement Of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Marketable securities - short-term
Available For Sale Securities Debt Securities Current
Accounts receivable from collaborations
Accounts Receivable Net Current
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Marketable securities - long-term
Available For Sale Securities Debt Securities Noncurrent
Property and equipment, net
Property Plant And Equipment Net
Operating lease right-of-use (ROU) assets
Operating Lease Right Of Use Asset
Other assets
Other Assets Noncurrent
Indefinite-lived intangible asset
Indefinite Lived Intangible Assets Excluding Goodwill
Goodwill
Goodwill
Total assets
Assets
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities And Stockholders Equity [Abstract]
Current liabilities
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued research and development expenses
Accrued Research And Development Expenses Current
Other accrued expenses
Other Accrued Liabilities Current
Operating lease liabilities - short-term
Operating Lease Liability Current
Total current liabilities
Liabilities Current
Deferred tax liabilities
Deferred Income Tax Liabilities Net
Deferred revenue
Contract With Customer Liability Noncurrent
Operating lease liabilities - long-term
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies
Commitments And Contingencies
Stockholders' equity
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding
Preferred Stock Value
Common stock, $0.001 par value; 100,000,000 shares authorized as of December 31, 2021 and December 31, 2020; 48,120,437 and 34,026,680 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' equity
Stockholders Equity
Total liabilities and stockholders' equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
Collaboration revenue
Revenue From Contract With Customer Including Assessed Tax
Operating expenses
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Impairment of goodwill and indefinite-lived intangible asset
Goodwill And Intangible Asset Impairment
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income
Nonoperating Income Expense [Abstract]
Interest and other income, net
Interest Income Other
Total other income
Nonoperating Income Expense
Loss before income taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax benefit
Income Tax Expense Benefit
Net loss
Net Income Loss
Other comprehensive loss
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent [Abstract]
Unrealized loss on marketable securities
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax
Net loss per share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Issuance of common stock upon cashless exercise of pre-funded warrants shares.
Issuance of common stock upon cashless exercise of pre-funded warrants.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-in Capital
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Loss
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit
Retained Earnings [Member]
Statement [Line Items]
Statement [Line Items]
Balance
Balance (in shares)
Shares Outstanding
Issuance of common stock under ATM equity offering program, net of issuance costs
Stock Issued During Period Value New Issues
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)
Stock Issued During Period Shares New Issues
Issuance of common stock upon exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Issuance of common stock upon exercise of stock options ( in shares )
Stock Issued During Period Shares Stock Options Exercised
Issuance of common stock under Employee Stock Purchase Plan (ESPP)
Stock Issued During Period Value Employee Stock Ownership Plan
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)
Stock Issued During Period Shares Employee Stock Ownership Plan
Issuance of common stock for settlement of restricted stock units (RSUs)
Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures
Issuance of shares of common stock for settlement of restricted stock units (RSUs) (in shares)
Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures
Issuance of common stock upon cashless exercise of pre-funded warrants
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants
Issuance of common stock upon cashless exercise of pre-funded warrants (in shares)
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants Shares
Stock-based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Net loss
Balance
Balance (in shares)
Accretion and amortization of investments In marketable debt securities.
Represent non cash rent expense.
Increase (decrease) in accrued research and development expenses.
Increase decrease in operating lease liabilities.
Proceeds from issuance of common stock under employee stock purchase plan.
Remeasurement of lease liabilities arising from modification of right of use assets.
Receivable from sale of microbiome assets included in prepaid expenses and other current assets.
Statement Of Cash Flows [Abstract]
Cash flows from operating activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation and amortization
Depreciation Depletion And Amortization
Non-cash in-process research and development (IPR&D) expense
Research And Development In Process
Stock-based compensation
Share Based Compensation
Net accretion and amortization of investments in marketable debt securities
Accretion And Amortization Of Investments In Marketable Debt Securities
Non-cash rent expense
Noncash Rent Expense
Deferred income tax benefit
Deferred Income Tax Expense Benefit
Loss on disposal of property and equipment
Gain Loss On Sale Of Property Plant Equipment
Gain on the sale of Microbiome assets
Gain Loss On Sale Of Business
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable from collaboration
Increase Decrease In Accounts Receivable
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Other assets
Increase Decrease In Other Noncurrent Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued research and development expenses
Increase Decrease In Accrued Research And Development Expenses
Other accrued expenses
Increase Decrease In Other Accrued Liabilities
Deferred revenue
Increase Decrease In Contract With Customer Liability
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Cash flows from investing activities
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Proceeds from sale of property and equipment
Proceeds From Sale Of Property Plant And Equipment
Purchase of IPR&D from an acquisition of assets
Payments To Acquire In Process Research And Development
Proceeds from the sale of Microbiome assets
Proceeds From Divestiture Of Businesses
Purchases of marketable securities
Payments To Acquire Available For Sale Securities Debt
Proceeds from maturities of marketable securities
Proceeds From Maturities Prepayments And Calls Of Available For Sale Securities
Proceeds from sale of marketable securities
Proceeds From Sale Of Available For Sale Securities Debt
Net cash provided by investing activities
Net Cash Provided By Used In Investing Activities
Cash flows from financing activities
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from the issuance of common stock under ATM equity offering program, net of issuance costs
Proceeds From Issuance Of Common Stock
Proceeds from the issuance of common stock under ESPP
Proceeds From Issuance Of Common Stock Under Employee Stock Purchase Plan
Proceeds from the exercise of stock options
Proceeds From Stock Options Exercised
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase (decrease) in cash and cash equivalents
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash and cash equivalents at the beginning of the period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Cash and cash equivalents at the end of the period
Supplemental non-cash investing and financing activities
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Operating lease liabilities arising from obtaining ROU assets
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Remeasurement of lease liabilities arising from modification of ROU assets
Remeasurement Of Lease Liabilities Arising From Modification Of Right Of Use Assets
Receivable from sale of Microbiome assets included in prepaid expenses and other current assets
Receivable From Sale Of Microbiome Assets Included In Prepaid Expenses And Other Current Assets
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of Business
Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block]
Accounting Policies [Abstract]
Summary of Significant Accounting Policies and Recent Accounting Pronouncements
Significant Accounting Policies [Text Block]
Investments Debt And Equity Securities [Abstract]
Investments in Marketable Securities
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Goodwill And Intangible Assets Disclosure [Abstract]
Goodwill and Indefinite-Lived Intangible Asset Impairment
Goodwill And Intangible Assets Disclosure [Text Block]
Payables And Accruals [Abstract]
Other Accrued Expenses
Accounts Payable And Accrued Liabilities Disclosure [Text Block]
Restructuring And Related Activities [Abstract]
Restructurings
Restructuring And Related Activities Disclosure [Text Block]
Equity [Abstract]
Stockholders' Equity
Stockholders Equity Note Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Collaborative and License Arrangement Disclosure.
Collaboration Agreement
Collaboration Agreement [Abstract]
Collaboration Agreements
Collaborative And License Arrangement Disclosure [Text Block]
Milestones and Research Agreements
Milestones and Research Agreements
Milestones And Research Agreements [Abstract]
Milestones and Research Agreements
Milestones And Research Agreements [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Lease Cost [Abstract]
Leases
Lessee Operating Leases [Text Block]
Compensation And Retirement Disclosure [Abstract]
Employee Benefit Plan
Compensation And Employee Benefit Plans [Text Block]
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Other risks and uncertainties.
Other Risks And Uncertainties
Other Risks And Uncertainties Policy [Text Block]
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Investments in Marketable Securities
Marketable Securities Policy
Goodwill and Indefinite-Lived Intangible Asset
Goodwill And Intangible Assets Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Property and Equipment, Net
Property Plant And Equipment Policy [Text Block]
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Revenue Recognition and Accounts Receivable from Collaborations
Revenue Recognition Policy [Text Block]
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Research and Development Expense and Accruals
Research And Development Expense Policy
Restructurings Charges
Costs Associated With Exit Or Disposal Activities Or Restructurings Policy [Text Block]
Variable Interest Entities
Consolidation Variable Interest Entity Policy
Income Taxes
Income Tax Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Concentration of risk.
Concentrations of Risk
Concentration Of Risk Policy Policy [Text Block]
Adoption of Recent Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Schedule of Fair Value of Financial Assets
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block]
Schedule of Changes in Contract Liabilities
Contract With Customer Asset And Liability Table [Text Block]
Schedule of Collaboration revenue recognized with the period
Schedule of Collaboration Revenue Recognized with the Period
Schedule Of Collaboration Revenue Recognized With Period Table [Text Block]
Schedule of Earnings Per Share, Basic and Diluted
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule of Investments in Marketable Available-for-Sale Securities
Schedule Of Available For Sale Securities Reconciliation Table [Text Block]
Schedule of Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of Other Accrued Expenses
Schedule Of Accrued Liabilities Table [Text Block]
Summary of Restructuring Costs
Schedule Of Restructuring And Related Costs [Text Block]
Schedule of restructuring charges.
Schedule of Restructuring Charges
Schedule Of Restructuring Charges Table [Text Block]
Schedule of accrued restructuring charges.
Schedule of Accrued Restructuring Charges
Schedule Of Accrued Restructuring Charges Table [Text Block]
Summary of Warrants to Purchase Shares of Company's Common Stock
Schedule Of Stockholders Equity Note Warrants Or Rights [Text Block]
Summary of Stock Option Activity and Related Information
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Restricted Stock Units and Related Information
Nonvested Restricted Stock Shares Activity Table [Text Block]
Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Recognized Stock-Based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Schedule of Deferred Income Tax Benefit
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Effective Income Tax Rate of Provision for Income Taxes
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Components of Deferred Taxes
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary of Net Operating Loss and Tax Credit Carryforwards
Summary Of Operating Loss Carryforwards [Text Block]
Activity Related to Gross Unrecognized Tax Benefits
Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block]
Schedule of Quantitative Information of Operating Leases
Lease Cost Table [Text Block]
Schedule of Maturities Operating Lease Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Operating segments (in segments)
Number Of Operating Segments
Represents the number of approved products.
FDA approved products (in products)
Number Of Approved Products
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Maximum
Maximum [Member]
Minimum
Minimum [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
PublicOffering
Public Offering
Public Offering [Member]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
ASU 2020-10
Accounting Standards Update202010 [Member]
Impairment loss
Impairment Of Long Lived Assets To Be Disposed Of
Estimated useful lives of property and equipment
Property Plant And Equipment Useful Life
Cash equivalents at fair value.
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Recurring
Fair Value Measurements Recurring [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1
Fair Value Inputs Level1 [Member]
Level 2
Fair Value Inputs Level2 [Member]
Level 3
Fair Value Inputs Level3 [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money market fund
Money Market Funds [Member]
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
U.S. and foreign commercial paper
Commercial Paper [Member]
U.S and foreign corporate debt securities
Corporate Debt Securities [Member]
Asset-backed securities
Asset Backed Securities [Member]
U.S. treasury securities
U S Treasury Securities [Member]
Cash equivalents
Cash Equivalents At Fair Value [Abstract]
Total cash equivalents
Cash And Cash Equivalents Fair Value Disclosure
Short-term marketable securities
Short Term Investments [Abstract]
Short-term marketable securities
Long-term marketable securities
Long Term Investments [Abstract]
Long-term marketable securities
Total assets measured at fair value
Assets Fair Value Disclosure
Impairment charges of goodwill and indefinite-lived assets
Fair value assets between levels transfers amount.
Fair value assets transfers between level 1, level 2 or level 3
Fair Value Assets Between Levels Transfers Amount
Contract with customer liability in additions.
Contract with customer liability in deduction.
Balance at Beginning of Period
Contract With Customer Liability
Additions
Contract With Customer Liability In Additions
Deductions
Contract With Customer Liability In Deduction
Balance at End of Period
Collaboration revenue recognized in period [Abstract]
Collaboration revenue recognized in the period from
Collaboration Revenue Recognized In Period [Abstract]
Amounts included in deferred revenue at the beginning of the period
Contract With Customer Liability Revenue Recognized
Performance obligations satisfied in previous period
Contract With Customer Performance Obligation Satisfied In Previous Period
Uncertain tax positions, income tax interest or penalties incurred
Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
Uncertain tax positions, income tax interest or penalties accrued
Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued
Number of pre-funded warrants to purchase shares of common stock outstanding
Class Of Warrant Or Right Outstanding
Number of pre-funded warrants sold to purchase of common stock
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Pre-funded warrants exercisable price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Numerator:
Net Income Loss [Abstract]
Denominator:
Weighted Average Number Of Shares Outstanding [Abstract]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Options
Employee Stock Option [Member]
Common stock subject to purchase under employee stock purchase program.
Common stock subject to purchase under ESPP
Common Stock Subject To Purchase Under Employee Stock Purchase Program [Member]
RSUs
Restricted Stock Units R S U [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of loss per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change In Accounting Principle Accounting Standards Update Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change In Accounting Principle Accounting Standards Update Adopted
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change In Accounting Principle Accounting Standards Update Immaterial Effect
Cash equivalents at carrying value and available for sale debt securities amortized cost.
Cash equivalents at carrying value and available for sale debt securities gross unrealized gain.
Cash equivalents at carrying value and available for sale debt securities gross unrealized loss.
Cash equivalents at carrying value and available for sale debt securities estimated fair value.
Schedule Of Available For Sale Securities [Table]
Schedule Of Available For Sale Securities [Table]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Cash equivalents
Cash Equivalents [Member]
Short-term marketable securities
Short Term Investments [Member]
Long term marketable securities.
Long-term marketable securities
Long Term Marketable Securities [Member]
Investments in marketable securities:
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Gross Unrealized Gain
Cash And Cash Equivalent Gross Unrealized Gain
Gross Unrealized Loss
Cash And Cash Equivalent Gross Unrealized Loss
Fair Value
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Gross Unrealized Gain
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Gross Unrealized Loss
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Amortized Cost
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Amortized Cost
Gross Unrealized Gain
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Gain
Gross Unrealized Loss
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Loss
Fair Value
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Estimated Fair Value
Short term marketable securities.
Short-term marketable securities
Short Term Marketable Securities [Member]
Available for sale securities maturity term
Debt Securities Available For Sale Term
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Lab equipment
Equipment [Member]
Office equipment
Office Equipment [Member]
Leasehold improvement
Leasehold Improvements [Member]
Property, Plant and Equipment
Property Plant And Equipment [Line Items]
Total property and equipment
Property Plant And Equipment Gross
Less: Accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Depreciation
Depreciation
Goodwill impairment charge
Goodwill Impairment Loss
Indefinite-lived intangible assets impairment charges
Impairment Of Intangible Assets Indefinitelived Excluding Goodwill
Accrued restructuring charges current.
Accrued expenses:
Accrued Liabilities Current [Abstract]
Accrued compensation
Employee Related Liabilities Current
Accrued restructuring charges
Accrued Restructuring Charges Current
Accrued professional fees and other
Accrued Professional Fees Current
Total accrued expenses
Accrued Liabilities Current
Restructuring and related cost incurred cost (benefit).
Schedule Of Restructuring And Related Costs [Table]
Schedule Of Restructuring And Related Costs [Table]
Restructuring Type
Restructuring Cost And Reserve [Axis]
Type of Restructuring
Type Of Restructuring [Domain]
Employee severance and related benefits.
Employee Severance and Related Benefits
Employee Severance And Related Benefits [Member]
Asset impairment and other costs.
Asset Impairment and Other Costs
Asset Impairment And Other Costs [Member]
Restructuring Cost And Reserve [Line Items]
Restructuring Cost And Reserve [Line Items]
Cumulative restructuring costs incurred through December 31, 2021
Restructuring And Related Cost Cost Incurred To Date1
Restructuring costs incurred
Restructuring And Related Cost Incurred Cost Benefit
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development
Research And Development Expense [Member]
General and Administrative
General And Administrative Expense [Member]
Restructuring charges
Accrued balance
Costs incurred
Restructuring Charges
Reductions for cash payments
Payments For Restructuring
Accrued balance
Restructuring charges for remaining payment obligations of leased equipment.
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Microbiome purchase agreement.
Microbiome Purchase Agreement
Microbiome Purchase Agreement [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others By Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others Type [Domain]
Regulatory.
Regulatory
Regulatory [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event
Subsequent Event [Member]
Balance Sheet Location
Balance Sheet Location [Axis]
Balance Sheet Location
Balance Sheet Location [Domain]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Member]
Costs incurred for remaining payment obligations of leased equipment
Restructuring Charges For Remaining Payment Obligations Of Leased Equipment
Potential Milestone Payments.
Consideration of assets sale agreement to be received.
Consideration from asset purchase agreement, entitled to receive
Consideration Of Assets Sale Agreement To Be Received
Consideration from asset purchase agreement
Proceeds From Sale Of Productive Assets
Potential milestone payments
Potential Milestone Payments
Reduction in research and development expense.
Sale consideration receivable.
Gain on sale assets
Gain Loss On Disposition Of Assets1
Reduction in research and development expense
Reduction In Research And Development Expense
Consideration due
Sale Consideration Receivable
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Two thousand and twenty at the market offerings.
2020 At the Market Offerings
Two Thousand And Twenty At The Market Offerings [Member]
Additional Shares Sold by Underwriters
Over Allotment Option [Member]
Subsidiary Sale Of Stock [Line Items]
Subsidiary Sale Of Stock [Line Items]
The value of common stock authorized to issue in a public offering.
Initial public offering value of shares authorized
Initial Public Offering Value Of Shares Authorized
Number of shares sold
Sale Of Stock Number Of Shares Issued In Transaction
Net proceeds from the issuance of common stock through equity plans
Proceeds From Issuance Initial Public Offering
Sale of stock, price Per warrant.
Threshold ownership percentage to exercise warrant.
Warrants exercisable description.
Number of shares sold
Sale of stock, price per share
Sale Of Stock Price Per Share
Sale of stock, price per warrant
Sale Of Stock Price Per Warrant
Ownership percentage to exercise warrant
Threshold Ownership Percentage To Exercise Warrant
Warrants exercisable description
Warrants Exercisable Description
Proceeds from sale of pre-funded warrants.
Proceeds from sale of pre-funded warrants
Proceeds From Sale Of Pre Funded Warrants
Class of warrant or right issuance dates.
Class of warrant or right expiration dates.
Class of Warrant or Right
Class Of Warrant Or Right [Axis]
Class of Warrant or Right
Class Of Warrant Or Right [Domain]
Warrants issued one.
Warrants Issued on December 16, 2019
Warrants Issued One [Member]
Issue date
Class Of Warrant Or Right Issuance Dates
Expiration date
Class Of Warrant Or Right Expiration Dates
Exercise Price per Share
Number of warrants outstanding
Number of warrants exercised.
Number of pre-funded warrants exercised
Number Of Warrants Exercised
Warrant to purchase of common stock
Class Of Warrant Or Right Number Of Securities Called By Each Warrant Or Right
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Employee Stock Purchase Plan
Employee Stock [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Chief Executive Officer
Executive Officer [Member]
Employees including executive officers.
Employees Including Executive Officers
Employees Including Executive Officers [Member]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
TwoThousandEighteenEmployeeStockPurchasePlanMember
2018 ESPP
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
Terminated Employees
Employee Severance [Member]
Share-based Compensation Arrangement by Share-based Payment Award
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Axis]
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Domain]
Number of Shares
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Options, Outstanding at beginning of period
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Option, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Option, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Option, Expired
Share Based Compensation Arrangement By Share Based Payment Award Options Expirations In Period
Option, Outstanding at end of period
Options vested and exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Weighted Average Exercise Price Per Share
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Options, Outstanding at beginning of period
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Option, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Option, Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Option, Expired
Share Based Compensation Arrangements By Share Based Payment Award Options Expirations In Period Weighted Average Exercise Price
Option, Outstanding at end of period
Options vested and exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Options Outstanding, Weighted Average Remaining Contractual Term (Years)
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Options Vested and Exercisable, Weighted Average Remaining Contractual Term (Years)
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Option, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Options, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Options, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Options vested and exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Weighted-average grant-date fair value of options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Total intrinsic value of options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Beginning of period
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Ending of period
Weighted Average Fair Value Per RSU at Grant Price
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Intrinsic Value Roll Forward
Beginning of period
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Ending of period
Total fair value of awards vested and settled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Total intrinsic value of awards vested and settled
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Vested
Number of awards vested and settled
The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.
Cumulative catch-up adjustment of stock-based compensation expense.
Forfeited
Outstanding awards
Total fair value of awards
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Amount
Stock-based compensation expense
Allocated Share Based Compensation Expense
Cumulative catch-up adjustment of stock-based compensation expense
Cumulative Catch Up Adjustment Of Stock Based Compensation Expense
Share based compensation arrangement by share based payment award number of shares per employee.
Maximum shares available for purchase by employees (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Number of common stock to be issued per offering
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Per Employee
Maximum number of common stock to be issued per offering
Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Shares Per Employee
Percentage of payroll deductions in ESPP
Share Based Compensation Arrangement By Share Based Payment Award Maximum Employee Subscription Rate
Purchase price after discount (in percent)
Sharebased Compensation Arrangement By Sharebased Payment Award Purchase Price Of Common Stock Percent
Number of common stock purchased by employees
Stock Issued During Period Shares Employee Stock Purchase Plans
Common stock, capital shares reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Share based compensation arrangement fair value assumptions exercise price.
Exercise price
Share Based Compensation Arrangement Fair Value Assumptions Exercise Price
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Risk-free rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected term (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Compensation expense:
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Unrecognized stock-based compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Unrecognized stock-based compensation expense expected to be recognized, term
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
The amount of reimbursable expenses.
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Collaborative Arrangement
Collaborative Arrangement [Member]
BeiGene Agreement
Bei Gene Agreement [Member]
Development and regulatory.
Development and Regulatory
Development And Regulatory [Member]
Net sales milestone payments.
Sales Milestone Payments
Net Sales Milestone Payments [Member]
BeiGene, Limited.
Bei Gene Limited
Bei Gene Limited [Member]
Other Assets
Other Noncurrent Assets [Member]
Arbutus agreement.
Arbutus Agreement
Arbutus Agreement [Member]
Antios agreement.
Antios Agreement
Antios Agreement [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Cost of reimbursable expenses
Cost Of Reimbursable Expenses
Contract with customer, liability, current
Contract With Customer Liability Current
Contract liability/deferred revenue
Accounts receivable from collaboration
Agreed to pay maximum amount development and regulatory costs.
Agreed to pay maximum amount development and regulatory costs
Agreed To Pay Maximum Amount Development And Regulatory Costs
Upfront cash payment received.
Upfront cash payment received
Upfront Cash Payment Received
Contract with customer, liability, noncurrent
Research and development expense
Incremental costs.
Incremental costs
Incremental Costs
Clinical trial collaboration costs incurred.
Costs incurred
Clinical Trial Collaboration Costs Incurred
Sublicensing fee.
Performance milestone payment.
Cash payments for and related to milestone.
Microbiome Targeted Colonic Delivery Program
License Agreement Terms [Member]
Door agreement.
Door Agreement
Doors Agreement [Member]
Milestone and Research Agreements:
Potential milestone payment
Purchase Commitment Remaining Minimum Amount Committed
Sublicensing Fee
Sublicensing Fee
Performance milestone payment
Performance Milestone Payment
Payment of milestone
Payment Of Milestone
Accrued expenses
License agreement term.
Up-front payments.
Success-based milestones payment.
Research and development funding charges.
License agreement term
Licenses Agreement Term
Up-front payment
Up Front Payments
Success-based milestones
Success Based Milestones Payment
Exercise and annual fees
Research And Development Arrangement Contract To Perform For Others Costs Incurred Gross
Research and development funding charges
Research And Development Funding Charges
Federal current and deferred income tax expense benefit.
State, current and deferred income tax expense benefit.
Current and deferred federal local tax expense benefit [Abstract]
Current and deferred state local tax expense benefit.
Federal:
Current And Deferred Federal Local Tax Expense Benefit [Abstract]
Current
Current Federal Tax Expense Benefit
Deferred
Deferred Federal Income Tax Expense Benefit
Federal, current and deferred income tax expense benefit
Federal Current And Deferred Income Tax Expense Benefit
State:
Current And Deferred State Local Tax Expense Benefit [Abstract]
Current
Current State And Local Tax Expense Benefit
Deferred
Deferred State And Local Income Tax Expense Benefit
State, current and deferred income tax expense benefit
State Current And Deferred Income Tax Expense Benefit
Income tax benefit
Effective income tax rate reconciliation return to provision adjustments.
Effective income tax rate reconciliation uncertain tax positions rate.
Effective income tax rate reconciliation impairment of goodwill.
Statutory federal income tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State taxes, net of federal tax benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Research and development tax credits
Effective Income Tax Rate Reconciliation Tax Credits
Return to provision adjustments
Effective Income Tax Rate Reconciliation Return To Provision Adjustments
Other
Effective Income Tax Rate Reconciliation Other Adjustments
Uncertain tax positions
Effective Income Tax Rate Reconciliation Uncertain Tax Positions Rate
Impairment of goodwill
Effective Income Tax Rate Reconciliation Impairment Of Goodwill
Stock-based compensation
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
Change in valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Income taxes benefit
Effective Income Tax Rate Continuing Operations
Deferred tax assets operating lease liabilities.
Deferred tax liabilities, operating lease right-of-use assets.
Deferred tax assets:
Deferred Tax Assets Net [Abstract]
Federal and state-operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Stock-based compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Operating lease liabilities
Deferred Tax Assets Operating Lease Liabilities
Research and development credits
Deferred Tax Assets Tax Credit Carryforwards Research
Other
Deferred Tax Assets Other
Total deferred tax assets
Deferred Tax Assets Gross
Valuation allowance
Deferred Tax Assets Valuation Allowance
Deferred tax asset, net of valuation allowance
Deferred Tax Assets Net
Deferred tax liabilities:
Deferred Tax Liabilities Net [Abstract]
In-process research and development
Deferred Tax Liabilities Deferred Expense Capitalized Research And Development Costs
Operating lease right-of-use assets
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Total deferred tax liabilities
Deferred Income Tax Liabilities
Net deferred tax liability
Deferred Tax Liabilities
Valuation allowance increased
Valuation Allowance Deferred Tax Asset Change In Amount
Expiration date of each operating loss carry forward
Income Taxes [Line Items]
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Federal
Domestic Country [Member]
State
State And Local Jurisdiction [Member]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name
Tax Credit Carryforward Name [Domain]
Research Tax Credit Carryforward
Research [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Expiration Years
Operating Loss Carry Forwards Expiration Period
Net operating losses
Deferred Tax Assets Operating Loss Carryforwards Not Subject To Expiration
Net operating losses
Deferred Tax Assets Operating Loss Carryforwards Subject To Expiration
Balances as of beginning of year
Unrecognized Tax Benefits
Increases related to prior year tax positions
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
Decreases related to prior year tax positions
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
Increases related to current year tax positions
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
Balances as of end of year
Leases [Abstract]
Operating lease, liability
Operating Lease Liability
Operating lease, right-of-use asset
Lease cost
Operating lease cost
Operating Lease Cost
Short-term lease cost
Short Term Lease Cost
Variable lease cost
Variable Lease Cost
Sublease income
Sublease Income
Total lease cost, net
Lease Cost
Operating cash flows from operating leases
Operating Lease Payments
ROU assets exchanged for new operating lease liabilities
Weighted-average remaining lease term - operating leases
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate - operating leases
Operating Lease Weighted Average Discount Rate Percent
2022
Lessee Operating Lease Liability Payments Due Next Twelve Months
2023
Lessee Operating Lease Liability Payments Due Year Two
2024
Lessee Operating Lease Liability Payments Due Year Three
Total
Lessee Operating Lease Liability Payments Due
Less: present value discount
Lessee Operating Lease Liability Undiscounted Excess Amount
Operating lease liabilities
Defined Contribution Plan, Employer Discretionary Contribution Amount
Defined Contribution Plan Employer Discretionary Contribution Amount