100000 - Document - Document And Entity Information
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100010 - Statement - CONSOLIDATED BALANCE SHEETS
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100020 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)
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100030 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
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100040 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Parenthetical)
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100050 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY
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100060 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
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100070 - Disclosure - Nature of Business
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100080 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements
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100090 - Disclosure - Related Party
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100100 - Disclosure - Investments in Marketable Securities
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100110 - Disclosure - Property and Equipment, Net
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100120 - Disclosure - Other Accrued Expenses
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100130 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets Impairment
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100140 - Disclosure - Restructurings
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100150 - Disclosure - Stockholders' Equity
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100160 - Disclosure - Stock-Based Compensation
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100170 - Disclosure - Collaboration Agreements
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100180 - Disclosure - Strategic License Agreements
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100190 - Disclosure - Income Taxes
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100200 - Disclosure - Leases
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100210 - Disclosure - Employee Benefit Plan
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100220 - Disclosure - Subsequent Event
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100230 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)
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100240 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Tables)
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100250 - Disclosure - Investments in Marketable Securities (Tables)
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100260 - Disclosure - Property and Equipment, Net (Tables)
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100270 - Disclosure - Other Accrued Expenses (Tables)
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100280 - Disclosure - Restructurings (Tables)
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100290 - Disclosure - Stockholders' Equity (Tables)
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100300 - Disclosure - Stock-Based Compensation (Tables)
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100310 - Disclosure - Collaboration Agreements (Tables)
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100320 - Disclosure - Income Taxes (Tables)
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100330 - Disclosure - Leases (Tables)
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100340 - Disclosure - Nature of Business - Additional Information (Details)
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100350 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Additional Information (Details)
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100360 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Fair Value of Financial Assets (Details)
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100370 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Changes in Contract Liabilities (Details)
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100380 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Collaboration Revenue Recognized with the Period (Details)
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100390 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Earnings Per Share, Basic and Diluted (Details)
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100400 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details)
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100410 - Disclosure - Related Party - Additional Information (Details)
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100420 - Disclosure - Investments in Marketable Securities - Schedule of Investments in Marketable Available-for-Sale Securities (Details)
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100430 - Disclosure - Investments in Marketable Securities - Additional Information (Details)
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100440 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details)
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100450 - Disclosure - Property and Equipment, Net - Additional Information (Details)
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100460 - Disclosure - Other Accrued Expenses - Schedule of Other Accrued Expenses (Details)
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100470 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets Impairment - Additional Information (Details)
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100480 - Disclosure - Restructurings - Additional Information (Details)
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100490 - Disclosure - Restructurings - Schedule of Accrued Restructuring Charges (Details)
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100500 - Disclosure - Stockholders' Equity - Additional Information (Details)
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100510 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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100520 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity and Related Information (Details)
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100530 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units and Related Information (Details)
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100540 - Disclosure - Stock-Based Compensation - Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants (Details)
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100550 - Disclosure - Stock-Based Compensation - Schedule of Recognized Stock-Based Compensation Expense (Details)
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100560 - Disclosure - Collaboration Agreements - Summary of Collaboration Revenue Recognized from Collaboration Agreements (Details)
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100570 - Disclosure - Collaboration Agreements - Additional Information (Details)
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100580 - Disclosure - Collaboration Agreements - Additional Information (Details 1)
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100580 - Disclosure - Collaboration Agreements - Additional Information (Details 1) [Default]
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100590 - Disclosure - Strategic License Agreements - Additional Information (Details)
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100600 - Disclosure - Income Taxes - Schedule of Income Tax Benefit (Details)
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100610 - Disclosure - Income Taxes - Effective Income Tax Rate of Provision for Income Taxes (Details)
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100620 - Disclosure - Income Taxes - Additional Information (Details)
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100630 - Disclosure - Income Taxes - Components of Deferred Taxes (Details)
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100640 - Disclosure - Income Taxes - Summary of Net Operating Loss and Tax Credit Carryforwards (Details)
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100650 - Disclosure - Income Taxes - Activity Related to Gross Unrecognized Tax Benefits (Details)
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100660 - Disclosure - Leases - Additional Information (Details)
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100670 - Disclosure - Leases - Schedule of Quantitative Information of Operating Leases (Details)
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100680 - Disclosure - Leases - Schedule of Maturities Operating Lease Liabilities (Details)
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100690 - Disclosure - Leases - Schedule of Maturities Operating Lease Liabilities (Details) 2
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100700 - Disclosure - Employee Benefit Plan - Additional Information (Details)
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100710 - Disclosure - Subsequent Event - Additional Information (Details)
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Auditor Firm ID
Auditor Firm ID
2024
Lessee, Operating Lease, Liability, to be Paid, Year One
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Document Transition Report
Document Transition Report
Amortized Cost, Short-term marketable securities
Debt Securities, Available-for-Sale, Amortized Cost, Current
Amortized Cost, Short-term marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options Outstanding, Weighted Average Remaining Contractual Term (Years)
Remaining performance obligation amount
Revenue, Remaining Performance Obligation, Amount
Money Market Funds [Member]
Money market fund
Deferred tax liabilities, operating lease right-of-use assets.
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Operating lease right-of-use assets
Increase (Decrease) in Other Accrued Liabilities
Other accrued expenses
Issuance costs
Payments of Stock Issuance Costs
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Percentage of workforce reduced
Restructuring Cost and Reserve [Line Items]
Restructuring Cost And Reserve [Line Items]
Geographical [Axis]
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Unvested RSUs
Restricted Stock Units (RSUs) [Member]
RSUs
Fair Value, Inputs, Level 1 [Member]
Level 1
Entity Public Float
Entity Public Float
Income Tax, Policy [Policy Text Block]
Income Taxes
Property, Plant and Equipment, Useful Life
Estimated useful lives of property and equipment
Potential Milestone Payments.
Potential Milestone Payments
Potential milestone payments
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Valuation allowance increased
Summary of Collaboration Revenue Recognized from Collaboration Agreements
Disaggregation of Revenue [Table Text Block]
Concentration Risk Type [Axis]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Percentage of premium to weighted average price immediately prior to delivery of notice of closing date
Percentage of Premium to Weighted Average Price Immediately Prior to Delivery of Notice of Closing Date
Percentage of premium to weighted average price immediately prior to delivery of notice of closing date.
Cash equivalents at carrying value and available for sale debt securities gross unrealized gain.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Gain
Gross Unrealized Gain
Deferred revenue - short-term
Deferred revenue - short-term ($30,915 and $- to a related party)
Contract with Customer, Liability, Current
Amortized Cost, Long-term marketable securities
Debt Securities, Available-for-Sale, Amortized Cost, Noncurrent
Amortized Cost, Long-term marketable securities
Title of Individual [Domain]
Title of Individual
Fair value of common stock purchased
Fair Value Of Common Stock Purchased
Fair value of common stock purchased.
Subsequent Events [Text Block]
Subsequent Event
Operating Lease, Liability, Noncurrent
Operating lease liabilities - long-term
Debt Securities, Available-for-Sale [Table]
Nonmonetary Transaction Type [Axis]
Related Party Transactions [Abstract]
Balance Sheet Location [Axis]
Balance Sheet Location
Assets, Current
Total current assets
Vesting [Domain]
Liabilities and Equity
Total liabilities and stockholders' equity
Entity Address, State or Province
Entity Address, State or Province
Deferred Tax Assets, Other
Other
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs
Reverse stock split ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Option, Outstanding at end of period
Options, Outstanding at beginning of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant-date fair value of options granted
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Fifth Year of Collaboration Agreement
Fifth Year of Collaboration [Member]
Fifth year of collaboration.
Goodwill and Intangible Assets, Policy [Policy Text Block]
Goodwill and Indefinite-Lived Intangible Asset
Trading Symbol
Trading Symbol
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax asset, net of valuation allowance
Common Stock, Shares, Issued
Common stock, shares issued
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation
Debt Securities, Available-for-Sale [Line Items]
Investments in marketable securities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Total fair value of awards vested and settled
Available for sale debt securities accumulated gross unrealized loss before tax noncurrent.
Available For Sale Debt Securities Accumulated Gross Unrealized Loss before Tax Noncurrent
Gross Unrealized Loss, Long-term marketable securities
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
Compensation and Employee Benefit Plans [Text Block]
Employee Benefit Plan
Development and regulatory.
Development And Regulatory [Member]
Development and Regulatory
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Effective income tax rate reconciliation uncertain tax positions rate.
Effective Income Tax Rate Reconciliation Uncertain Tax Positions Rate
Uncertain tax positions
Effective income tax rate reconciliation return to provision adjustments.
Effective Income Tax Rate Reconciliation Return To Provision Adjustments
Return to provision adjustments
Shares, Outstanding
Balance (in shares)
Balance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Common stock, capital shares reserved for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Total Intrinsic Value
Options, Granted
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee
Maximum number of common stock to be issued per offering
Entity Address, City or Town
Entity Address, City or Town
Related Party Transaction [Line Items]
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate - operating leases
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Net operating losses
Regulatory and Commercial Milestones
Regulatory And Commercial Milestones [Member]
Regulatory and commercial milestones.
Subsequent Event [Member]
Subsequent Event
Subsequent Event Type [Axis]
Subsequent Event Type
Cash and cash equivalent gross unrealized loss.
Cash And Cash Equivalent Gross Unrealized Loss
Gross Unrealized Loss
Schedule of accrued restructuring charges.
Schedule Of Accrued Restructuring Charges Table [Text Block]
Schedule of Accrued Restructuring Charges
Increases related to prior year tax positions
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Collaboration Agreement
Collaboration Agreement [Abstract]
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Schedule of Income Tax Benefit
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Non-US [Member]
Outside of United States
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Proceeds from maturities of marketable securities
Liabilities, Current [Abstract]
Current liabilities
Assets, Current [Abstract]
Current assets
Deferred tax assets operating lease liabilities.
Deferred Tax Assets Operating Lease Liabilities
Operating lease liabilities
Counterparty Name
Counterparty Name [Axis]
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Statement of Stockholders' Equity [Abstract]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Operating Lease, Liability, Current
Operating lease liabilities - short-term
Marketable Securities, Policy [Policy Text Block]
Investments in Marketable Securities
Revenue recognized
Collaboration revenue ($4,430 and $- from a related party)
Collaboration revenue
Microbiome purchase agreement.
Microbiome Purchase Agreement [Member]
Microbiome Purchase Agreement
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Restructuring charges incurred
Restructuring Charges
Costs incurred
Restructuring Charges, Total
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Statutory federal income tax rate
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Issuance of common stock for settlement of restricted stock units (RSUs)
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Percentage share of profits and operating loss for products
Percentage Share of Profits and Operating Loss for Products
Percentage share of profits and operating loss for products.
Plan Name [Domain]
Plan Name
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Related Party
Related Party [Member]
Transaction price upfront payment
Transaction Price Upfront Payment
Transaction price upfront payment.
Assets, Fair Value Disclosure
Total assets measured at fair value
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Foreign
Current Foreign Tax Expense (Benefit)
Liabilities, Current
Total current liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Collaboration revenue
Collaboration Revenue [Member]
Collaboration revenue.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Financial Instruments [Domain]
Financial Instruments
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Total Intrinsic Value
Award Date [Domain]
Issuance of common stock under Employee Stock Purchase Plan (ESPP)
Stock Issued During Period, Value, Employee Stock Purchase Plan
Award Type [Axis]
Award Type
Lessee, Operating Leases [Text Block]
Leases
Lessee, Operating Lease, Lease Not yet Commenced, Existence of Option to Extend [true false]
Other revenue
Service, Other [Member]
Plan Name [Axis]
Plan Name
Reverse Stock Split Member
Reverse Stock Split [Member]
Reverse stock split member.
Geographical [Domain]
Assets
Total assets
Operating Lease, Right-of-Use Asset
Operating lease right-of-use (ROU) assets
Operating lease, right-of-use asset
Entity Registrant Name
Entity Registrant Name
Asset-Backed Securities [Member]
Asset-backed securities
Executive Officer [Member]
Executive Officer
Related Party, Type [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Intrinsic Value, Amount Per Share [Abstract]
Weighted Average Fair Value Per RSU at Grant Price
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Nonvested Restricted Stock Shares Activity [Table Text Block]
Summary of Restricted Stock Units and Related Information
Expiration date of each operating loss carry forward
Operating Loss Carry Forwards Expiration Period
Expiration Years
Retained Earnings [Member]
Accumulated Deficit
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Ending of period
Beginning of period
Outstanding awards
Gain (Loss) on Disposition of Assets
Gain on sale assets
Gain (Loss) on Disposition of Assets, Total
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Number of common stock purchased by employees
Minimum [Member]
Minimum
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Schedule of Investments in Marketable Available-for-Sale Securities
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies and Recent Accounting Pronouncements
Operating Lease, Liability
Operating lease, liability
Operating lease liabilities
Operating Lease, Liability, Total
Employee severance and related benefits
Share-Based Payment Arrangement, Tranche One [Member]
Market-based Vesting Conditions
Revenue [Policy Text Block]
Revenue Recognition and Accounts Receivable from Collaborations
US Government Agencies Debt Securities [Member]
U.S and foreign corporate debt securities
Equity Component [Domain]
Equity Component
Options to purchase common stock
Employee Stock Option [Member]
Options
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Premium received on common stock purchase
Premium Received On Common Stock Purchase
Premium received on common stock purchase.
Measurement Frequency [Axis]
Measurement Frequency
Sublease Income
Sublease income
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted Average Exercise Price Per Share
Gain (Loss) on Disposition of Business
Gain on the sale of Microbiome assets
Entity Current Reporting Status
Entity Current Reporting Status
Common Stock, Shares Authorized
Common stock, shares authorized
Research and Development Expense
Research and development
Research and development expense
Research and Development Expense, Total
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Assets [Abstract]
ASSETS
Total proceeds
Proceeds from Issuance of Common Stock
Proceeds from the issuance of common stock under ATM equity offering program, net of issuance costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Maximum shares available for purchase by employees (in shares)
Subsidiary, Sale of Stock [Line Items]
Subsidiary Sale Of Stock [Line Items]
Common stock, $0.001 par value; 150,000,000 shares authorized as of December 31, 2023 and December 31, 2022; 5,482,752 and 4,074,552 shares issued and outstanding as of December 31, 2023 and December 31, 2022, respectively
Common Stock, Value, Issued
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from sale of property and equipment
Proceeds from Sale of Property, Plant, and Equipment, Total
Contract with Customer, Liability, Revenue Recognized
Amounts included in deferred revenue at the beginning of the period
Accrued Liabilities, Current
Accrued expenses
Total accrued expenses
Current Fiscal Year End Date
Current Fiscal Year End Date
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
Auditor Name
Auditor Name
Performance milestone payment.
Performance Milestone Payment
Performance milestone payment
Operating Income (Loss)
Loss from operations
Schedule of Collaboration revenue recognized with the period
Schedule Of Collaboration Revenue Recognized With Period Table [Text Block]
Schedule of Collaboration Revenue Recognized with the Period
Cash equivalents at carrying value and available for sale debt securities estimated fair value.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Estimated Fair Value
Fair Value
Total deferred
Deferred Income Tax Expense (Benefit)
Deferred income tax benefit
Income tax expense
Income tax expense
Income Tax Expense (Benefit)
Percentage cover of research and development costs
Percentage Cover of Research and Development Costs
Percentage cover of research and development costs.
Lessee, operating lease, lease not yet commenced, option to extend
Lessee, Operating Lease, Lease Not yet Commenced, Option to Extend
Research and Development Expense
Research and Development Expense [Member]
Research and Development
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decreases related to prior year tax positions
Number of fellow-contributed programs
Number of Fellow-contributed Programs
Number of fellow-contributed programs.
Lessee, Leases [Policy Text Block]
Leases
Payments for Restructuring
Reductions for cash payments
Contract with Customer, Performance Obligation Satisfied in Previous Period
Performance obligations satisfied in previous period
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Other Accrued Expenses
Revenue percentage
Concentration Risk, Percentage
Short term marketable securities.
Short Term Marketable Securities [Member]
Short-term marketable securities
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Equipment [Member]
Lab equipment
Seventh Year of Collaboration Agreement
Seventh Year of Collaboration [Member]
Seventh year of collaboration.
Restructuring one time termination cost.
Restructuring one-time termination Cost
Number of directors, right to designate in company board
Number of Directors, Right to Designate in Board
Number of directors right to designate in board.
Collaboration agreement termination description
Collaboration Agreement Termination Description
Collaboration agreement termination description.
Threshold payment of opt-in fee
Threshold Payment of Opt-in Fee
Threshold payment of opt-in fee.
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Option, Outstanding
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increases related to current year tax positions
Arbutus agreement.
Arbutus Agreement [Member]
Arbutus Biopharma Agreement
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Represents the number of approved products.
Number Of Approved Products
FDA approved products (in products)
Sale of stock, price per share
Sale of Stock, Price Per Share
Cumulative restructuring charges
Cumulative Restructuring Charges
Cumulative Restructuring Charges
Operating Expenses [Abstract]
Operating expenses
Property, Plant and Equipment [Abstract]
Entity Voluntary Filers
Entity Voluntary Filers
Subsequent Events [Abstract]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss
Available for sale debt securities accumulated gross unrealized gain before tax current.
Available for Sale Debt Securities Accumulated Gross Unrealized Gain before Tax Current
Gross Unrealized Gain, Short-term marketable securities
Other Assets, Noncurrent
Other assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Option, Granted
Other Accrued Liabilities, Current
Other accrued expenses
Equity [Text Block]
Stockholders' Equity
Depreciation
Depreciation
Depreciation, Total
Initial non-cancellable term
Initial Non Cancellable Term
Initial non-cancellable term.
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
Net operating losses
Share based compensation arrangement fair value assumptions exercise price.
Share Based Compensation Arrangement Fair Value Assumptions Exercise Price
Exercise price
Purchase agreement consideration amount received during the period
Purchase Agreement Consideration Amount Received During The Period
Purchase agreement consideration amount received during the period.
Research and development funding charges.
Research And Development Funding Charges
Research and development funding charges
Equity, Attributable to Parent [Abstract]
Stockholders' equity
Increase (decrease) in accrued research and development expenses.
Increase Decrease In Accrued Research And Development Expenses
Accrued research and development expenses
Lease, Cost [Table Text Block]
Schedule of Quantitative Information of Operating Leases
Entity [Domain]
Gain (Loss) on Disposition of Property Plant Equipment
Loss on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Summary of Warrants to Purchase Shares of Company's Common Stock
License agreement term.
Licenses Agreement Term
License agreement term
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Maturities Operating Lease Liabilities
Two thousand and twenty at the market offerings.
Two Thousand And Twenty At The Market Offerings [Member]
2020 At the Market Offerings
2020 ATM
Deferred Tax Liabilities, Net
Net deferred tax liability
Deferred Tax Liabilities, Net, Total
Accounting Policies [Abstract]
Purchase agreement consideration entitled to receive
Purchase Agreement Consideration Amount Receivable
Purchase agreement consideration amount receivable.
Premium on purchase of common stock
Sale Of Stock Consideration Premium On Purchase Of Common Stock
Sale of stock consideration premium on purchase of common stock.
Proceeds received from transaction
Upfront equity investment
Sale of Stock, Consideration Received on Transaction
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award
Capitalized and amortized costs period
Capitalized And Amortized Costs Period
Capitalized and amortized costs period.
Other Noncurrent Assets [Member]
Other Assets
Lease not yet commence, term of contract
Lessee, Operating Lease, Lease Not yet Commenced, Term of Contract
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share - basic
Customer Concentration Risk
Customer Concentration Risk [Member]
Purchase price per share of additional shares description
Purchase Price Per Share of Additional Shares Description
Purchase price per share of additional shares description.
Commitments and Contingencies
Commitments and contingencies
Debt Securities, Available-for-Sale, Term
Available for sale securities maturity term
Income Statement [Abstract]
Marketable securities
Short-term marketable securities
Fair Value, Short-term marketable securities
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Related Party, Type [Axis]
Performance conditions not yet Met
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Schedule of Changes in Contract Liabilities
Operating Lease, Cost
Operating lease cost
Short-Term Lease, Cost
Short-term lease cost
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Uncertain tax positions, income tax interest or penalties incurred
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Retirement Benefits [Abstract]
Costs incurred
Restructuring Charges Except Non-cash Stock Based Compensation Expense
Restructuring charges except non-cash stock based compensation expense.
Restructuring Type [Axis]
Restructuring Type
Statistical Measurement [Domain]
Statistical Measurement
Net cash provided by (used in) operating activities
Net Cash Provided by (Used in) Operating Activities
TwoThousandEighteenEmployeeStockPurchasePlanMember
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
2018 ESPP
Proceeds from the issuance of common stock to a related party, net of issuance costs
Proceeds From Issuance Of Common Stock to Related Party
Proceeds from issuance of common stock to related party.
Incremental costs.
Incremental Costs
Incremental costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Total intrinsic value of awards vested and settled
All Award Types
Award Type
Document Period End Date
Document Period End Date
Statistical Measurement [Axis]
Statistical Measurement
Unamortized contract costs
Unamortized Contract Costs
Unamortized contract costs.
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share - diluted
Product and Service [Domain]
Lease, Cost [Abstract]
Lease cost
Deferred Tax Assets, Operating Loss Carryforwards
Federal and state-operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Unrecognized Tax Benefits
Balances as of end of year
Balances as of beginning of year
Consideration of assets sale agreement to be received.
Consideration Of Assets Sale Agreement To Be Received
Consideration from asset purchase agreement, entitled to receive
Concentration Risk Benchmark [Domain]
Short-Term Investments [Abstract]
Short-term marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Stock-based compensation arrangement by share-based payment award, requisite service period
Proceeds from issuance of common stock under employee stock purchase plan.
Proceeds From Issuance Of Common Stock Under Employee Stock Purchase Plan
Proceeds from the issuance of common stock under ESPP
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Options vested and exercisable
Related Party Transaction [Domain]
Fair Value, Recurring [Member]
Recurring
Additional Paid in Capital, Common Stock
Additional paid-in capital
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Number of Shares
Variable consideration
Variable Consideration On Milestone
Variable consideration on milestone.
US Treasury Securities [Member]
U.S. treasury securities
Accrued restructuring charges current.
Accrued Restructuring Charges Current
Accrued balance
Accrued balance
Accrued restructuring charges
Schedule of Restructuring and Related Costs [Table]
Schedule Of Restructuring And Related Costs [Table]
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Accrued research and development expenses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of stock options ( in shares )
Options exercised
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Cash equivalents at carrying value and available for sale debt securities gross unrealized loss.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Gross Unrealized Loss
Gross Unrealized Loss
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Interactive Data Current
Entity Interactive Data Current
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Equity [Abstract]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: present value discount
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Maximum percentage of then-outstanding voting capital stock
Maximum Percentage Of Then Outstanding Voting Capital Stock
Maximum percentage of then-outstanding voting capital stock.
Percentage of corporate alternative minimum tax.
Percentage of corporate alternative minimum tax
Percentage of corporate alternative minimum tax
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Nonmonetary Transaction Type [Domain]
Equity Components [Axis]
Equity Components
Increase (Decrease) in Accounts Receivable
Accounts receivable from collaboration
Restructuring and Related Activities [Abstract]
Investments, Debt and Equity Securities [Abstract]
Increase decrease in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Office Equipment [Member]
Office equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Local Phone Number
Local Phone Number
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment
Sale of Stock [Axis]
Sale of Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options vested and exercisable
Federal
Current Federal Tax Expense (Benefit)
Current
Strategic License Agreements [Abstract]
Strategic license agreements abstract.
Research Tax Credit Carryforward [Member]
Research Tax Credit Carryforward
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Issuance of common stock for settlement of restricted stock units (RSUs) (in shares)
Other Risks and Uncertainties
Other risks and uncertainties.
Other Risks And Uncertainties Policy [Text Block]
Statement of Cash Flows [Abstract]
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Income Tax Authority [Domain]
Income Tax Authority
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Concentration Risk Benchmark [Axis]
Document Annual Report
Document Annual Report
Receivable from sale of Microbiome assets included in prepaid expenses and other current assets
Receivable From Sale Of Microbiome Assets Included In Prepaid Expenses And Other Current Assets
Receivable from sale of microbiome assets included in prepaid expenses and other current assets.
Proceeds received in collaboration agreement
Proceeds from Collaborators
Common Stock, Par or Stated Value Per Share
Common stock, par value
Dilutive Securities, Effect on Basic Earnings Per Share, Total
Dilutive Securities, Effect on Basic Earnings Per Share
Dilutive effect of securities
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation expense expected to be recognized, term
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Shares reserved for issuance (in shares)
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Maximum [Member]
Maximum
Number of years of standstill provision
Number Of Years Of Standstill Provision
Number of years of standstill provision.
Related Party Transaction [Axis]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of Business
Restructuring costs reversal of stock-based compensation expense
Restructuring costs reversal
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Activity Related to Gross Unrecognized Tax Benefits
Number of years of standstill and lockup provisions
Number of Years of Standstill and Lockup Provisions
Number of years of standstill and lockup provisions.
Fair Value, Inputs, Level 3 [Member]
Level 3
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Cash equivalents at fair value.
Cash Equivalents At Fair Value [Abstract]
Cash equivalents
Strategic License Agreements:
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Net (decrease) increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Payables and Accruals [Abstract]
General and Administrative Expense
General and Administrative Expense [Member]
General and Administrative
Milestone payment receivable
Purchase Agreement Milestone Payment Receivable
Purchase agreement milestone payment receivable.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Option, Forfeited
Document Financial Statement Error Correction [Flag]
Upfront cash payment received.
Upfront Cash Payment Received
Upfront cash payment received
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
City Area Code
City Area Code
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
State
Deferred State and Local Income Tax Expense (Benefit)
Deferred
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Investments in Marketable Securities
Interest Income, Other
Interest and other income, net
Customer [Domain]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares and pre-funded warrants outstanding - basic
Restructuring and Related Costs [Table Text Block]
Summary of Restructuring Costs
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
Employee Stock [Member]
Employee Stock Purchase Plan
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expense and Accruals
Statement [Table]
Statement [Table]
Fair value assets between levels transfers amount.
Fair Value Assets Between Levels Transfers Amount
Fair value assets transfers between level 1, level 2 or level 3
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity and Related Information
Schedule of Related Party Transactions, by Related Party [Table]
Available for sale debt securities accumulated gross unrealized gain before tax noncurrent.
Available For Sale Debt Securities Accumulated Gross Unrealized Gain before Tax Noncurrent
Gross Unrealized Gain, Long-term marketable securities
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Assumptions Used to Estimate Fair Values of Stock Options Grants
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Contract liabilities recognized
Document Fiscal Period Focus
Document Fiscal Period Focus
Lessee, Operating Lease, Liability, to be Paid
Total
Door agreement.
Doors Agreement [Member]
Door Agreement
The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Amount
Total fair value of awards
Revenue from Contract with Customer Benchmark
Revenue from Contract with Customer Benchmark [Member]
Related Party
Related Party Transactions Disclosure [Text Block]
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
Accrued Professional Fees, Current
Accrued professional fees and other
Statement [Line Items]
Statement [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of loss per share
Lease, Cost
Total lease cost, net
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Components of Deferred Taxes
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable from collaboration
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts receivable from collaboration
Customer [Axis]
Cash equivalents at carrying value and available for sale debt securities amortized cost.
Cash Equivalents At Carrying Value And Available For Sale Debt Securities Amortized Cost
Amortized Cost
Common Stock [Member]
Common Stock
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Amortized Cost
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Recognized Stock-Based Compensation Expense
Realized gains and losses
Realized Investment Gains (Losses)
Realized Investment Gains (Losses), Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Options vested and exercisable
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Proceeds from Sale of Debt Securities, Available-for-Sale
Proceeds from sale of marketable securities
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Variable Interest Entities
ASU 2016-13
Accounting Standards Update 2016-13 [Member]
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Cover [Abstract]
Vesting [Axis]
Number of years of lockup provision
Number Of Years Of Lockup Provision
Number of years of lockup provision.
Current:
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Bei Gene Agreement [Member]
BeiGene Agreement
BeiGene agreement.
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Uncertain tax positions, income tax interest or penalties accrued
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Issuance of common stock to a related party, net of issuance costs ( in shares)
Stock Issued During Period Shares Common Stock To Related Party
Stock issued during period shares common stock to related party.
Sale of Stock [Domain]
Sale of Stock
Option Indexed to Issuer's Equity, Type [Domain]
Option Indexed to Issuer's Equity, Type
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted
Proceeds from Sale of Productive Assets
Consideration from asset purchase agreement
Proceeds from Sale of Productive Assets, Total
Proceeds from Divestiture of Businesses
Proceeds from the sale of Microbiome assets
Impairment, Intangible Asset, Indefinite-Lived (Excluding Goodwill), Statement of Income or Comprehensive Income [Extensible Enumeration]
Security Exchange Name
Security Exchange Name
Third Year of Collaboration Agreement
Third Year of Collaboration [Member]
Third year of collaboration.
Domestic Tax Authority [Member]
Federal
Strategic License Agreements
Strategic License Agreements [Text Block]
Strategic license agreements text block.
Recently Adopted Accounting Standards and Accounting Pronouncements to Be Adopted
New Accounting Pronouncements, Policy [Policy Text Block]
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Property, Plant and Equipment, Gross
Total property and equipment
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Percentage of then-outstanding voting capital stock subject to stockholder approval
Percentage of Then-outstanding Voting Capital Stock Subject to Stockholder Approval
Percentage of then-outstanding voting capital stock subject to stockholder approval.
State
Current State and Local Tax Expense (Benefit)
Current
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease liabilities arising from obtaining ROU assets
ROU assets exchanged for new operating lease liabilities
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Option, Forfeited
Legal Entity [Axis]
Financial Instrument [Axis]
Financial Instrument
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Entity Emerging Growth Company
Entity Emerging Growth Company
Milestone payment, diligence maintenance fees
Milestone Payment Diligence Maintenance Fees
Milestone payment, diligence maintenance fees.
Amendment Flag
Amendment Flag
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Other Accrued Expenses
Asset impairment and other costs.
Asset Impairment And Other Costs [Member]
Asset Impairment and Other Costs
Contract with customer liability in additions.
Contract With Customer Liability In Additions
Additions
Collaboration term
Collaboration Term
Collaboration term.
Accounting Standards Update [Domain]
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
U.S. and foreign commercial paper
U S And Foreign Commercial Paper [Member]
U.S. and foreign commercial paper.
Restructuring and Related Activities Disclosure [Text Block]
Restructurings
Payments to Acquire Debt Securities, Available-for-Sale
Purchases of marketable securities
Silicon Valley Bank.
Silicon Valley Bank Member
Silicon Valley Bank
Leases [Abstract]
Premium on common stock received
Premium on Common Stock Received
Premium on Common Stock Received
Securities Act File Number
Entity File Number
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred Tax Assets, Gross
Total deferred tax assets
Agreed to pay maximum amount development and regulatory costs.
Agreed To Pay Maximum Amount Development And Regulatory Costs
Agreed to pay maximum amount development and regulatory costs
Goodwill and Intangible Assets Disclosure [Abstract]
Gilead Sciences, Inc.
Gilead
Gilead Sciences Incorporated [Member]
Gilead sciences incorporated.
Unrealized gain (loss) on marketable debt securities
Unrealized gain (loss) on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Cash Equivalents [Member]
Cash equivalents
Share-Based Payment Arrangement [Abstract]
Summary of Operating Loss Carryforwards [Table Text Block]
Summary of Net Operating Loss and Tax Credit Carryforwards
Regulatory.
Regulatory [Member]
Regulatory
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Ending of period
Beginning of period
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Operating Expenses
Total operating expenses
Number of timepoints of program
Number of Timepoints of Program
Number of timepoints of program.
BeiGene, Ltd. (BeiGene)
BeiGene, Limited.
Bei Gene Limited [Member]
Bei Gene Limited
Auditor Location
Auditor Location
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Long-term marketable securities
Fair Value, Long-term marketable securities
Debt Securities, Available-for-Sale, Noncurrent
Collaborative Arrangement [Member]
Collaborative Arrangement
Reverse stock split description
Stockholders' Equity, Reverse Stock Split
Entity Address, Address Line Two
Entity Address, Address Line Two
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Number of Operating Segments
Operating segments (in segments)
Percentage of then-outstanding voting capital stock
Percentage of Then Outstanding Voting Capital Stock
Percentage of then outstanding voting capital stock.
Title of Individual [Axis]
Title of Individual
Number of share Purchased
Sale of Stock, Number of Shares Issued in Transaction
Number of shares sold
Investment Type [Axis]
Investment Type
Income Taxes [Line Items]
Income Taxes [Line Items]
Income Taxes [Line Items]
Net (accretion) amortization of investments in marketable debt securities
Net (accretion) amortization of investments in marketable debt securities
(Accretion) Amortization Of Investments In Marketable Debt Securities
(Accretion) amortization of investments in marketable debt securities.
Issuance of common stock upon cashless exercise of pre-funded warrants shares.
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants Shares
Issuance of common stock upon cashless exercise of pre-funded warrants (in shares)
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Commercial Paper [Member]
U.S. and foreign commercial paper
Entity Address, Address Line One
Entity Address, Address Line One
Cash and Cash Equivalents, Fair Value Disclosure
Total cash equivalents
Fair Value
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Compensation expense:
Option Indexed to Issuer's Equity, Type [Axis]
Option Indexed to Issuer's Equity, Type
Antidilutive Securities [Axis]
Antidilutive Securities
Granted in August 2022.
Granted In August Two Thousand Twenty Two [Member]
Granted in August 2022
Percentage of outstanding voting of common stock held
Percentage of Outstanding Voting of Common Stock Held
Percentage of Outstanding Voting of Common Stock Held
Employees including executive officers.
Employees Including Executive Officers [Member]
Employees Including Executive Officers
Subsequent Event Type [Domain]
Subsequent Event Type
Income Statement Location [Axis]
Income Statement Location
Variable Lease, Cost
Variable lease cost
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Impairment of Intangible Assets, Indefinite-Lived (Excluding Goodwill)
Indefinite-lived intangible assets impairment charges
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Costs Associated with Exit or Disposal Activities or Restructurings, Policy [Policy Text Block]
Restructurings Charges
Capitalized research expense
Fair Value, Inputs, Level 2 [Member]
Level 2
Closing bid price of stock
Share Price
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Product and Service [Axis]
Deferred revenue - long-term
Deferred revenue - long-term ($55,379 and $- to a related party)
Contract with Customer, Liability, Noncurrent
Title of 12(b) Security
Title of 12(b) Security
Remeasurement of lease liabilities arising from modification of right of use assets.
Remeasurement Of Lease Liabilities Arising From Modification Of Right Of Use Assets
Remeasurement of lease liabilities arising from modification of ROU assets
PublicOffering
Public Offering [Member]
Public Offering
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Percentage of payroll deductions in ESPP
Net sales milestone payments.
Net Sales Milestone Payments [Member]
Sales Milestone Payments
Expected equity financing completion date
Expected Equity Financing Completion Date
Expected equity financing completion date.
Collaboration agreement termination term
Collaboration Agreement Termination Term
Collaboration agreement termination term.
Antios agreement.
Antios Agreement [Member]
Antios Agreement
Investments [Domain]
Investments
Accounting Standards Update [Axis]
Prepaid Expenses and Other Current Assets [Member]
Prepaid Expenses and Other Current Assets
Restructuring costs asset impairment and other costs.
Restructuring costs asset impairment and other costs
Purchase Commitment, Remaining Minimum Amount Committed
Potential milestone payment
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities
State and Local Jurisdiction [Member]
State
Goodwill, Impairment Loss
Goodwill impairment charge
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Subsequent Event [Table]
Represent non cash rent expense.
Noncash Rent Expense
Non-cash rent expense
Common stock subject to purchase under employee stock purchase program.
Common Stock Subject To Purchase Under Employee Stock Purchase Program [Member]
Common stock subject to purchase under ESPP
Contract with Customer, Liability
Balance at End of Period
Balance at Beginning of Period
Contract liability/deferred revenue
Contract with Customer, Liability, Total
Long term marketable securities.
Long Term Marketable Securities [Member]
Long-term marketable securities
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents
Defined Contribution Plan, Employer Discretionary Contribution Amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options Vested and Exercisable, Weighted Average Remaining Contractual Term (Years)
Potential proceeds from equity financing
Potential Proceeds from Equity Financing
Potential proceeds from equity financing.
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free rate
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited
Restructuring Costs, Total
Restructuring Costs
Restructuring costs
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Schedule of Fair Value of Financial Assets
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Concentration Risk Type [Domain]
Income Statement Location [Domain]
Income Statement Location
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Option, Granted
Cash and cash equivalent gross unrealized gain.
Cash And Cash Equivalent Gross Unrealized Gain
Gross Unrealized Gain
Potential proceeds from collaboration extension fees
Potential Proceeds from Collaboration Extension Fees
Potential proceeds from collaboration extension fees.
Document Type
Document Type
Sale consideration receivable.
Sale Consideration Receivable
Consideration due
Net cash (used in) provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Collaborative and License Arrangement Disclosure.
Collaborative And License Arrangement Disclosure [Text Block]
Collaboration Agreements
Counterparty Name
Counterparty Name [Domain]
Goodwill and Intangible Assets Disclosure [Text Block]
Goodwill and Indefinite-Lived Intangible Asset Impairment
Other
Deferred Tax Liabilities, Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Forfeited
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Total Intrinsic Value
Options, Forfeited
Short-Term Investments [Member]
Short-term marketable securities
Entity Filer Category
Entity Filer Category
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental non-cash investing and financing activities
Balance Sheet Location [Domain]
Balance Sheet Location
Increase (Decrease) in Other Noncurrent Assets
Other assets
Contract cost recognized
Contract Costs Recognized
Contract costs recognized.
Gillead Collaboration Agreement
Option, License and Collaboration Agreement
Option, License and Collaboration Agreement [Member]
Option, license and collaboration agreement.
Number of days volume considered for weighted average price to calculate premium
Number of Days Volume Considered for Weighted Average Price to Calculate Premium
Number of days volume considered for weighted average price to calculate premium.
Accrued Liabilities, Current [Abstract]
Accrued expenses:
Nonoperating Income (Expense)
Total other income
The value of common stock authorized to issue in a public offering.
Initial Public Offering Value Of Shares Authorized
Initial public offering value of shares authorized
Liabilities
Total liabilities
Issuance of common stock upon cashless exercise of pre-funded warrants.
Issuance Of Common Stock Upon Cashless Exercise Of Pre Funded Warrants
Issuance of common stock upon cashless exercise of pre-funded warrants
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Available for sale debt securities accumulated gross unrealized loss before tax current.
Available for Sale Debt Securities Accumulated Gross Unrealized Loss before Tax Current
Gross Unrealized Loss, Short-term marketable securities
Equity, Attributable to Parent
Balance
Balance
Total stockholders' equity
Gilead Equity Agreements
Equity Agreements [Member]
Equity agreements.
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Number of shares issued in connection with reverse stock split
Stock Issued During Period, Shares, Reverse Stock Splits
Net Income (Loss)
Net loss
Net loss
Nonoperating Income (Expense) [Abstract]
Other income
Proceeds from Issuance Initial Public Offering
Net proceeds from the issuance of common stock through equity plans
Net proceeds
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Accrued interest receivable
Accured Interest Receivable
Accured Interest Receivable
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State taxes, net of federal tax benefit
Award Date [Axis]
Corporate Debt Securities [Member]
U.S and foreign corporate debt securities
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Statement of Financial Position [Abstract]
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares and pre-funded warrants outstanding - diluted
Collaboration revenue recognized in period [Abstract]
Collaboration Revenue Recognized In Period [Abstract]
Collaboration revenue recognized in the period from
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Effective Income Tax Rate of Provision for Income Taxes
Impairment of long-lived assets
Impairment of Long-Lived Assets to be Disposed of
Income taxes provision (benefit)
Effective Income Tax Rate Reconciliation, Percent
Federal
Deferred Federal Income Tax Expense (Benefit)
Deferred
Issuance of common stock to a related party, net of issuance costs
Stock Issued During Period Value Common Stock To Related Party
Stock issued during period value common stock to related party.
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term - operating leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Purchase price after discount (in percent)
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Income Tax Disclosure [Text Block]
Income Taxes
Deferred Tax Assets, Net [Abstract]
Deferred tax assets:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Option, Outstanding at end of period
Options, Outstanding at beginning of period
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Earnings Per Share, Basic and Diluted
Contract with customer liability in deduction.
Contract With Customer Liability In Deduction
Deductions
Leasehold Improvements [Member]
Leasehold improvement
Concentration of risk.
Concentration Of Risk Policy Policy [Text Block]
Concentrations of Risk
Income Tax Authority [Axis]
Income Tax Authority
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule of restructuring charges.
Schedule Of Restructuring Charges Table [Text Block]
Schedule of Restructuring Charges
Restructuring and related cost incurred cost benefit
Restructuring And Related Cost Incurred Cost Benefit
Restructuring costs incurred
Restructuring charges
Total current
Current Income Tax Expense (Benefit)
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Measurement Frequency [Domain]
Measurement Frequency
Percentage of premium to weighted average price immediately prior to date of purchase
Percentage of Premium to Weighted Average Price Immediately Prior to Date of Purchase
Percentage of premium to weighted average price immediately prior to date of purchase.
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Reduction in research and development expense.
Reduction In Research And Development Expense
Reduction in research and development expense
Type of Restructuring [Domain]
Type of Restructuring
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of awards vested and settled
Vested
Stock Issued During Period, Shares, New Issues
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)
Number of shares sold
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
Lease expiration, month and year
Lease Expiration, Month And Year
Lease expiration, month and year.
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash and cash equivalents at the end of the period
Cash and cash equivalents at the beginning of the period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Income Tax Disclosure [Abstract]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Employee severance and related benefits.
Employee Severance And Related Benefits [Member]
Employee Severance and Related Benefits